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S8502

Sigma-Aldrich

(−)-Scopolamine methyl bromide

≥98% (HPLC), powder

Sinônimo(s):

Hyoscine methyl bromide, Methscopolamine bromide

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1 G
R$ 632,00
5 G
R$ 2.505,00

R$ 632,00

Previsão de entrega em17 de abril de 2025

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1 G
R$ 632,00
5 G
R$ 2.505,00

About This Item

Fórmula empírica (Notação de Hill):
C18H24NO4 · Br
Número CAS:
155-41-9
Peso molecular:
398.29
Número CE:
205-844-5
Número MDL:
MFCD00078560
Código UNSPSC:
12352116
ID de substância PubChem:
24278714
NACRES:
NA.77

R$ 632,00

Previsão de entrega em17 de abril de 2025

Solicite uma grande encomenda

Nível de qualidade

200

Ensaio

≥98% (HPLC)

Formulário

powder

atividade óptica

[α]25/D −25°, c = 5 in H2O(lit.)

cor

white

solubilidade

H2O: 50 mg/mL

cadeia de caracteres SMILES

[Br-].[H][C@]12C[C@@H](C[C@]([H])([C@@]3([H])O[C@@]13[H])[N+]2(C)C)OC(=O)[C@H](CO)c4ccccc4

InChI

1S/C18H24NO4.BrH/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11;/h3-7,12-17,20H,8-10H2,1-2H3;1H/q+1;/p-1/t12-,13-,14-,15+,16-,17+;/m1./s1

chave InChI

CXYRUNPLKGGUJF-RAFJPFSSSA-M

Informações sobre genes

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

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Aplicação

(−)-Scopolamine methyl bromide was administered to rats to inhibit the peripheral cholinergic effects induced by pilocarpine.10,11

Ações bioquímicas/fisiológicas

Competitive muscarinic acetylcholine receptor antagonist.
Scopolamine is an anti-muscarinic and cholinolytic alkaloid that inhibits parasympathetic-cholinergic system.7 The central effects include hallucinations, disorientation, restlessness and euphoria.8 Scopolamine disturb the stimulus detection performance in rats by interfering with the reticular cholinergic pathways.9

Atenção

Shelf-life of the powder is at least five years when stored at room temperature.

Pictogramas

Exclamation markEnvironment
GHS07,GHS09

Palavra indicadora

Warning

Frases de perigo

H312 + H332,H400

Classificações de perigo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
0000253869
0000190854
0000241910
SLCM8890
0000190859

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Michal Kielbinski et al.
Developmental neurobiology, 78(7), 718-735 (2018-04-18)
Malformations of cortical development (MCD) are a common cause of intractable seizures in humans. Among these, focal cortical dysplasia (FCD) poses an outstanding challenge. There are several subtypes of FCD that show significant variation in pathology and clinical presentation. All
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The binding of orally administered imidafenacin, used to treat overactive bladders, to muscarinic receptors in rat tissue was characterized based on pharmacokinetics. The binding in six tissues including bladder tissue was measured using [N-methyl-(3)H] scopolamine methyl chloride ([(3)H]NMS). Pharmacokinetic parameters
Maxime Lévesque et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(38), 13264-13272 (2012-09-21)
High-frequency oscillations (HFOs; 80-500 Hz) are thought to mirror the pathophysiological changes occurring in epileptic brains. However, the distribution of HFOs during seizures remains undefined. Here, we recorded from the hippocampal CA3 subfield, subiculum, entorhinal cortex, and dentate gyrus to
Zuzanna Setkowicz et al.
Epilepsia, 44(10), 1267-1273 (2003-09-27)
To determine whether brains irradiated at different stages of prenatal development also have different postnatal susceptibility to seizures evoked by pilocarpine. Pregnant Wistar rats were exposed to a single 1.0-Gy dose of gamma rays on gestation days 13, 15, 17
Nicholas H Varvel et al.
Neuropharmacology, 224, 109356-109356 (2022-12-03)
Cognitive comorbidities can substantially reduce quality of life in people with epilepsy. Inflammation is a component of all chronic diseases including epilepsy, as well as acute events like status epilepticus (SE). Neuroinflammation is the consequence of several broad signaling cascades
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