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S7809

Sigma-Aldrich

SKF-96365

≥98% (HPLC), solid

Sinônimo(s):

1-[β-(3-(4-Methoxyphenyl)propoxy)-4-methoxyphenethyl]-1H-imidazole hydrochloride, 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole

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5 MG
R$ 1.924,00

R$ 1.924,00

Disponível para enviar em14 de abril de 2025Detalhes

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5 MG
R$ 1.924,00

About This Item

Fórmula empírica (Notação de Hill):
C22H26N2O3 · HCl
Número CAS:
130495-35-1
Peso molecular:
402.91
Número MDL:
MFCD00236407
Código UNSPSC:
12352200
ID de substância PubChem:
24278710
NACRES:
NA.77

R$ 1.924,00

Disponível para enviar em14 de abril de 2025Detalhes

Solicite uma grande encomenda

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

solid

cor

white

solubilidade

DMSO: >20 mg/mL
H2O: >20 mg/mL

cadeia de caracteres SMILES

Cl.COc1ccc(CCCOC(Cn2ccnc2)c3ccc(OC)cc3)cc1

InChI

1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4,15-16H2,1-2H3;1H

chave InChI

FWLPKVQUECFKSW-UHFFFAOYSA-N

Aplicação

SKF-96365 has been used as :
  • a nonselective transient receptor potential 6 (TRPC6) blocker in human podocytes[1]
  • an antagonist of store-operated Ca2+ influx in neurons[2]
  • an inhibitor for transient receptor potential 3 (TRPC3) in mice[3]

Ações bioquímicas/fisiológicas

SKF-96365 with an alkylated imidazole ring is a selective inhibitor of receptor-mediated Ca2+ entry and voltage-gated Ca2+ entry .[4] SKF-96365 mediated depolarization of smooth cardiac muscle membrane and had no impact on the acetylcholine (ACh)-induced depolarization.[5] It is an inhibitor for SOCE (store-operated calcium entry). It also inhibits Homer1 protein expression.[6] SKF-96365 elicits protective functionality in 1-methyl-4-phenylpyridinium(MPP) mediated cytotoxicity.[6]

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
0000386438
0000361572
0000361572
0000386438
065M4606V

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Protective effects of SKF-96365, a non-specific inhibitor of SOCE, against MPP+-induced cytotoxicity in PC12 cells: potential role of Homer1
Chen T, et al.
PLoS ONE, 8(1), e55601-e55601 (2013)
Effects of inhibitors of nonselective cation channels on the acetylcholine-induced depolarization of circular smooth muscle from the guinea-pig stomach antrum
Hotta A, et al.
Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi, 41(6), 313-327 (2005)
J E Merritt et al.
The Biochemical journal, 271(2), 515-522 (1990-10-15)
A novel inhibitor of receptor-mediated calcium entry (RMCE) is described. SK&F 96365 (1-(beta-[3-(4-methoxy-phenyl)propoxy]-4-methoxyphenethyl)-1H- imidazole hydrochloride) is structurally distinct from the known 'calcium antagonists' and shows selectivity in blocking RMCE compared with receptor-mediated internal Ca2+ release. Human platelets, neutrophils and endothelial
Arnaud Guilbert et al.
BMC cancer, 8, 125-125 (2008-05-03)
TRP channels have been shown to be involved in tumour generation and malignant growth. However, the expression of these channels in breast cancer remains unclear. Here we studied the expression and function of endogenous TRPC6 channels in a breast cancer
Marc Anderson et al.
Journal of cellular physiology, 229(4), 434-442 (2013-09-17)
Angiotensin II (AII) plays a major role in the progression of chronic kidney diseases. Podocytes are essential components of the ultrafiltration apparatus, and are targets for AII signaling. AII has been shown to increase generation of reactive oxygen species (ROS)
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