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Documentos

R0658

Sigma-Aldrich

RN-1734

≥98% (HPLC)

Sinônimo(s):

2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide

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About This Item

Fórmula empírica (Notação de Hill):
C14H22Cl2N2O2S
Número CAS:
946387-07-1
Peso molecular:
353.31
Número MDL:
MFCD00129453
Código UNSPSC:
12352200
ID de substância PubChem:
329823990
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

powder

cor

white to off-white

solubilidade

DMSO: >20 mg/mL

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

ClC1=C(S(N(C(C)C)CCNC(C)C)(=O)=O)C=CC(Cl)=C1

InChI

1S/C14H22Cl2N2O2S/c1-10(2)17-7-8-18(11(3)4)21(19,20)14-6-5-12(15)9-13(14)16/h5-6,9-11,17H,7-8H2,1-4H3

chave InChI

IHYZMEAZAIFMTN-UHFFFAOYSA-N

Aplicação

RN-1734 has been used as a transient receptor potential vanilloid 4 (TRPV4) blocker to study its effects on differentiation of a corneal epithelial cell model, RCE1(5T5) cells.

Ações bioquímicas/fisiológicas

RN-1734 is a selective TRPV4 antagonist.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

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Jacqueline Martínez-Rendón et al.
Journal of cellular physiology, 232(7), 1794-1807 (2016-11-22)
TRPV4 (transient receptor potential vanilloid 4) is a cation channel activated by hypotonicity, moderate heat, or shear stress. We describe the expression of TRPV4 during the differentiation of a corneal epithelial cell model, RCE1(5T5) cells. TRPV4 is a late differentiation
TRPV4 regulates tight junctions and affects differentiation in a cell culture model of the corneal epithelium
Martinez R, et al.
Journal of Cellular Physiology, 232(7), 1794-1807 (2017)
Silvia Ghirga et al.
Journal of the Optical Society of America. A, Optics, image science, and vision, 37(4), 643-652 (2020-05-14)
It has been recently demonstrated that the exposure of naive neuronal cells to light-at the basis of optogenetic techniques and calcium imaging measurements-may alter neuronal firing. Indeed, understanding the effect of light on nongenetically modified neurons is crucial for a
Vittorio Abbonante et al.
Haematologica, 102(7), 1150-1160 (2017-04-16)
Megakaryocytes (MK) in the bone marrow (BM) are immersed in a network of extracellular matrix components that regulates platelet release into the circulation. Combining biological and bioengineering approaches, we found that the activation of transient receptor potential cation channel subfamily
Hemant Kumar et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(9), 1943-1955 (2020-01-25)
Currently, the role of transient receptor potential vanilloid type 4 (TRPV4), a nonselective cation channel in the pathology of spinal cord injury (SCI), is not recognized. Herein, we report the expression and contribution of TRPV4 in the pathology of scarring
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