RAB0431
Mouse Shh-N ELISA Kit
for serum, plasma and cell culture supernatant
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1 KIT
R$ 3.289,00
R$ 3.289,00
Previsão de entrega em16 de abril de 2025
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1 KIT
R$ 3.289,00
About This Item
Código UNSPSC:
41116158
NACRES:
NA.32
R$ 3.289,00
Previsão de entrega em16 de abril de 2025
Produtos recomendados
reatividade de espécies
mouse
embalagem
kit of 96 wells (12 strips x 8 wells)
técnica(s)
ELISA: suitable
capture ELISA: suitable
entrada
sample type cell culture supernatant(s)
sample type serum
sample type plasma
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 5 pg/mL
standard curve range: 4.1-1000 pg/mL
método de detecção
colorimetric
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Informações sobre genes
mouse ... Shh(20423)
Descrição geral
The Mouse Shh-N (Sonic Hedgehog N Terminus) ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of mouse Shh-N in serum, plasma, cell culture supernatants and urine.
Imunogênio
Recombinant Mouse Sonic Hedgehog (N-terminus)
Aplicação
For research use only. Not for use in diagnostic procedures.
Mouse Shh-N ELISA Kit has been used to measure serum sonic hedgehog (Shh) level.[1]
Mouse Shh-N ELISA Kit has been used to measure serum sonic hedgehog (Shh) level.[1]
Ações bioquímicas/fisiológicas
Sonic hedgehog (Shh) is a secreted glycoprotein involved in embryonic morphogenic development of several tissues. It has a role in fracture healing and regeneration.[2][3] In the canonical pathway, the protein associates with its receptor Patched (Ptc-1), de-represses Smoothened (Smo) and activates the Gli family of transcription factors.[3] Mutations in the Shh pathway have been linked to developmental diseases and cancer.[4] Shh plays a vital role in axon growth and guidance throughout the brain development. Shh stimulates neurite outgrowth by overcoming neurite growth inhibitory environment associated with glial scar.[3]
Outras notas
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
Componentes do kit também disponíveis separadamente
Nº do produto
Descrição
SDS
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Met. Corr. 1
Código de classe de armazenamento
8A - Combustible corrosive hazardous materials
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Sonic hedgehog stimulates neurite outgrowth in a mechanical stretch model of reactive-astrogliosis.
Berretta A
Scientific Reports, 6:21896-6:21896 (2016)
M V Machado et al.
Gut, 64(7), 1148-1157 (2014-07-24)
Caspase-2 is an initiator caspase involved in multiple apoptotic pathways, particularly in response to specific intracellular stressors (eg, DNA damage, ER stress). We recently reported that caspase-2 was pivotal for the induction of cell death triggered by excessive intracellular accumulation
An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth.
Shi X
Nature Communications, 5:5425-5:5425 (2014)
Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.
Machado MV
Gut, 64(7), 1148-1157 (2015)
Lin Ding et al.
Cellular and molecular gastroenterology and hepatology, 11(5), 1251-1266 (2020-12-22)
Helicobacter pylori infection in humans typically begins with colonization of the gastric antrum. The initial Th1 response occasionally coincides with an increase in gastrin secretion. Subsequently, the gastritis segues to chronic atrophic gastritis, metaplasia, dysplasia and distal gastric cancer. Despite
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