Pular para o conteúdo
Merck
Todas as fotos(1)

Documentos

R4393

Sigma-Aldrich

Roxithromycin

95.0-102.0% (HPLC)

Sinônimo(s):

Erythromycin 9-(-O-[2-methoxyethoxy]methyloxime)

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Fórmula empírica (Notação de Hill):
C41H76N2O15
Número CAS:
80214-83-1
Peso molecular:
837.05
Número MDL:
MFCD00214389
Código UNSPSC:
51282308
ID de substância PubChem:
24899369
NACRES:
NA.85

Ensaio

95.0-102.0% (HPLC)

forma

powder or crystals

solubilidade

chloroform: soluble 10 mg/mL

espectro de atividade do antibiótico

Gram-negative bacteria
Gram-positive bacteria

Modo de ação

protein synthesis | interferes

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)C(=N/OCOCCOC)\C(C)C(O)C1(C)O

InChI

1S/C41H76N2O15/c1-15-29-41(10,49)34(45)24(4)31(42-53-21-52-17-16-50-13)22(2)19-39(8,48)36(58-38-32(44)28(43(11)12)18-23(3)54-38)25(5)33(26(6)37(47)56-29)57-30-20-40(9,51-14)35(46)27(7)55-30/h22-30,32-36,38,44-46,48-49H,15-21H2,1-14H3/b42-31+

chave InChI

RXZBMPWDPOLZGW-FEMONOMJSA-N

Procurando produtos similares? Visita Guia de comparação de produtos

Descrição geral

Chemical structure: macrolide

Aplicação

Roxithromycin is a semi-synthetic macrolide antibiotic. Roxithromycin is used to block bacterial protein synthesis. Clinically, it is used to treat respiratory tract, urinary and soft tissue infections. It has a similar antimicrobial spectrum as erythromycin, but is the preferred treatment for certain gram-negative bacteria, such as Legionella pneumophila.

Ações bioquímicas/fisiológicas

Roxithromycin impairs NADPH oxidase activation and alters translocation of its cytosolic components to the neutrophil membrane. It is similar in composition, chemical structure and mechanism of action to erythromycin, azithromycin, and clarithromycin. Roxithromycin binds to the subunit 50S of the bacterial ribosome, inhibiting the translocation of peptides.
Semisynthetic erythromycin derivative. Impairs NADPH oxidase activation and alters translocation of its cytosolic components to the neutrophil membrane.

Embalagem

1g,10g

Outras notas

Keep container tightly closed in a dry and well-ventilated place.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302

Declarações de precaução

P264 - P270 - P301 + P312 - P501

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Os clientes também visualizaram

Slide 1 of 8

1 of 8

Ramoplanin

Sigma-Aldrich

R1781

Ramoplanin

Erythromycin BioReagent, suitable for cell culture

Sigma-Aldrich

E5389

Erythromycin

Clarithromycin 96.0-102.0% (HPLC)

Sigma-Aldrich

A3487

Clarithromycin

Erythromycin meets USP testing specifications

Sigma-Aldrich

E0774

Erythromycin

Spiramycin

Sigma-Aldrich

S9132

Spiramycin

Azithromycin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1088

Azithromycin

Umbelliferone analytical standard

Supelco

54826

Umbelliferone

Rifamycin SV sodium salt potency: ≥ 900 IU/mg (anhydrous basis)

Sigma-Aldrich

R8626

Rifamycin SV sodium salt

Nikola Marjanović et al.
Pharmacological research, 63(5), 389-397 (2011-02-15)
Macrolide antibiotics are known to exert anti-inflammatory actions in vivo, including certain effects in COPD patients. In order to investigate the immunomodulatory profile of activity of macrolide antibiotics, we have studied the effects of azithromycin, clarithromycin, erythromycin and roxithromycin on
Patorn Piromchai et al.
The Cochrane database of systematic reviews, (5)(5), CD008233-CD008233 (2011-05-13)
Chronic rhinosinusitis (CRS) is a common health problem which significantly affects quality of life. A wide range of medical and surgical therapies have been used to treat CRS. Both systemic and topical antibiotics are used with the aim of eliminating
K Adrjanowicz et al.
Molecular pharmaceutics, 9(6), 1748-1763 (2012-05-01)
Antibiotics are chemical compounds of extremely important medical role. Their history can be traced back more than one hundred years. Despite the passing time and significant progress made in pharmacy and medicine, treatment of many bacterial infections without antibiotics would
X Wang et al.
Journal of veterinary pharmacology and therapeutics, 35(3), 282-289 (2011-07-14)
Tulathromycin is a macrolide antimicrobial agent proposed for therapeutic use in treatment of porcine and bovine respiratory disease. In this study, the absolute bioavailability of tulathromycin solution was investigated in pigs. Eight pigs, with body weight of 20.5 ± 1.6
[Bacillary angiomatosis in HIV infection. Update apropos of a case treated with roxithromycin].
M Duong et al.
Annales de medecine interne, 143(2), 107-109 (1992-01-01)
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica