P8399

Psoralen

≥99% (HPLC)

• Sinônimo(s): 6,7-Furanocoumarin, 7H-Furo[3,2-g]benzopyran-7-one, Ficusin, Furo[3,2-g]coumarin
• Fórmula empírica (Notação de Hill): C₁₁H₆O₃
• Número CAS: 66-97-7
• Peso molecular: 186.16
• Beilstein: 152784
• Número CE: 200-639-7
• Número MDL: MFCD00010520
• Código UNSPSC: 12352200
• ID de substância PubChem: 24898918
• NACRES: NA.77

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥99% (HPLC)
• Formulário: powder
• fluorescência: λ_ex 335 nm; λ_em 460 nm (pH 7.0)
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O=C1Oc2cc3occc3cc2C=C1
• InChI: 1S/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H
• chave InChI: ZCCUUQDIBDJBTK-UHFFFAOYSA-N

Descrição

Aplicação

Photochemical reagent for the investigation of nucleic acid structure and function.

Psoralen has been used:

• as a crosslinker for dsRNA for in- situ hybridization studies[1]
• in testing melanin dispersal effects in fish scale melanophores[2]
• to test its stimulatory effects in osteoblast a cell proliferation assay[3]
• as a reference standard in high-performance liquid chromatography (HPLC)[4]

Ações bioquímicas/fisiológicas

Psoralen belongs to the linear type furanocoumarins.[5] It intercalates and induces interstrand cross-links in DNA. On UV exposure psoralen is excited leading to irreversible intercalation with DNA by covalent bond formation.[5] This property of psoralen ultraviolet A light (PUVA) is exploited in treating skin diseases and cutaneous T-cell lymphoma.[5] However, usage psoralen also leads to hepatotoxicity[6] and cytotoxicity by the generation of psoralen photoproducts (POPs).[7] It may be useful in treating osteoporosis[8]

Características e benefícios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302,H317
• Declarações de precaução: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Classificações de perigo: Acute Tox. 4 Oral - Skin Sens. 1
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves