P6249
p53 human
recombinant, expressed in E. coli, buffered aqueous glycerol solution
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50 μG
R$ 6.028,00
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50 μG
R$ 6.028,00
About This Item
Código UNSPSC:
12352202
NACRES:
NA.25
Produtos recomendados
fonte biológica
human
Nível de qualidade
recombinante
expressed in E. coli
Ensaio
≥90% (SDS-PAGE)
Formulário
buffered aqueous glycerol solution
nº de adesão UniProt
aplicação(ões)
genomic analysis
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Informações sobre genes
human ... TP53(7157)
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Descrição geral
p53 is regulated by MDM2, which acts as a negative regulator of p53 transcription by promoting its degradation by functioning as an E3 ubiquitin ligase which recognizes the N′ terminal transactivation domain. [1]
Aplicação
Useful for the study of postranslational modification of p53, or protein-protein interaction studies.
Ações bioquímicas/fisiológicas
p53 gene is highly conserved and expressed in normal tissues. It is the most commonly mutated gene in human cancer and more then 500 gene mutations have been described in various types of malignancies, hematologic as well as solid tumors. Intact p53 function is essential for the maintenance of the non-tumorogenic phenotype of cells. Thus, p53 plays a vital role in suppressing the development of cancer.
propriedades físicas
GST-tagged, full-length human p53
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Dania Alarcon-Vargas et al.
Carcinogenesis, 23(4), 541-547 (2002-04-19)
The p53-Mdm2 paradigm represents the best-studied relationship between a tumor suppressor gene which functions as a transcription factor and an oncogene, which functions primarily as an E3 protein ligase. The intimate relationship between these two partners has expanded to include
Alejandra Ward et al.
BMC cancer, 11, 71-71 (2011-02-18)
Hepatocellular carcinoma (HCC), one of the most common cancers world-wide occurs twice as often in men compared to women. Predisposing conditions such as alcoholism, chronic viral hepatitis, aflatoxin B1 ingestion, and cirrhosis all contribute to the development of HCC. We
Se Kyung Lee et al.
PloS one, 10(8), e0124658-e0124658 (2015-08-05)
Overexpression of p53 is the most frequent genetic alteration in breast cancer. Recently, many studies have shown that the expression of mutant p53 differs for each subtype of breast cancer and is associated with different prognoses. In this study, we
Cristina Muñoz-San Martín et al.
Analytical and bioanalytical chemistry, 412(24), 6177-6188 (2020-01-29)
Proteases are involved in cancer' taking part in immune (dis)regulation, malignant progression and tumour growth. Recently, it has been found that expression levels of one of the members of the serine protease family, trypsin, is upregulated in human cancer cells
BAP1 immunohistochemistry and p16 FISH to separate benign from malignant mesothelial proliferations.
Brandon S Sheffield et al.
The American journal of surgical pathology, 39(7), 977-982 (2015-01-31)
A variety of immunohistochemical (IHC) stains have been proposed to mark either benign or malignant mesothelial proliferations. Loss of the p16 tumor suppressor (CDKN2A), through homozygous deletions of 9p21, is a good marker of mesotheliomas but lacks sensitivity. Recent reports
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