P302-05
Porcine Pulmonary Artery Endothelial Cells: PPAEC (Cryovial)
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About This Item
Código UNSPSC:
41106514
NACRES:
NA.81
Produtos recomendados
fonte biológica
Porcine pulmonary artery (Normal healthy)
Nível de qualidade
forma
solid
embalagem
pkg of 500,000 cells
fabricante/nome comercial
Cell Applications, Inc
modo de crescimento
Adherent
cariótipo
2n = 38
morfologia
Endothelial
técnica(s)
cell culture | mammalian: suitable
doença(s) relevante(s)
diabetes; cardiovascular diseases
Condições de expedição
dry ice
temperatura de armazenamento
−196°C
Descrição geral
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PPAEC have been used in a pioneer study of endothelial cell motility, where it was determined that asymmetric dimethylarginine (ADMA), an inhibitor of nitric oxide production and a cardiovascular risk factor, decreased PKG-mediated phosphorylation of VASP, leading to downregulation of Rac1 and induction of stress fibers and focal adhesions via RhoA/ROCK dependent mechanism, leading to decreased cell motility, and increase in endothelial permeability, thus linking vascular repair and function with NO production (Wojciak-Stothard, 2007, 2009). PPAEC were also used to assess endothelial adhesion to decellularized porcine arteries in order to develop grafts for human vascular repair (Xiong, 2013).
PPAEC have been used in a pioneer study of endothelial cell motility, where it was determined that asymmetric dimethylarginine (ADMA), an inhibitor of nitric oxide production and a cardiovascular risk factor, decreased PKG-mediated phosphorylation of VASP, leading to downregulation of Rac1 and induction of stress fibers and focal adhesions via RhoA/ROCK dependent mechanism, leading to decreased cell motility, and increase in endothelial permeability, thus linking vascular repair and function with NO production (Wojciak-Stothard, 2007, 2009). PPAEC were also used to assess endothelial adhesion to decellularized porcine arteries in order to develop grafts for human vascular repair (Xiong, 2013).
Origem de linhagem celular
Artery
Aplicação
cardiovascular function, screening of drug candidates, angiogenesis, vasodilator function, transport of deoxygenated bloood from heart to lungs
Componentes
Porcine Endothelial Cell Growth Medium that contains 10% FBS and 10% DMSO
Nota de preparo
- 1st passage, >500,000 cells in Porcine Endothelial Cell Growth Medium that contains 10% FBS and 10% DMSO
- Can be cultured at least 16 doublings
Rotina de subcultura
Please refer to the PPAEC Culture Protocol.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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