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Documentos

P2254

Sigma-Aldrich

Poly-L-proline

suitable for ligand binding assays, Mol wt 1,000-10,000

Sinônimo(s):

L-Proline homopolymer

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About This Item

Fórmula empírica (Notação de Hill):
C5H9NO2
Número CAS:
Peso molecular:
115.13
Número MDL:
Código UNSPSC:
12352209
ID de substância PubChem:
NACRES:
NA.26

product name

Poly-L-proline, mol wt 1,000-10,000

forma

powder

peso molecular

1,000-10,000

técnica(s)

ligand binding assay: suitable

cor

white

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

OC(=O)C1CCCN1

InChI

1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)

chave InChI

ONIBWKKTOPOVIA-UHFFFAOYSA-N

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Aplicação


  • Highly sensitive and selective electrochemical sensor for simultaneous determination of gallic acid, theophylline and caffeine using poly(l-proline) decorated carbon nanotubes in biological and food samples.: This study presents an innovative electrochemical sensor that utilizes poly-L-proline decorated carbon nanotubes for the simultaneous detection of gallic acid, theophylline, and caffeine. This sensor demonstrates high sensitivity and selectivity, making it suitable for applications in both biological and food samples (Aschemacher NA et al., 2024).

  • Water-assisted and protein-initiated fast and controlled ring-opening polymerization of proline N-carboxyanhydride.: This research explores the water-assisted and protein-initiated ring-opening polymerization of proline N-carboxyanhydride, leading to the rapid and controlled synthesis of poly-L-proline. The study highlights the method′s efficiency and potential for producing high-quality poly-L-proline for various applications (Hu Y et al., 2022).

  • Phosphorylation of the actin-binding protein profilin2a at S137 modulates bidirectional structural plasticity at dendritic spines.: This study examines the role of poly-L-proline regions in the actin-binding protein profilin2a, specifically focusing on its phosphorylation at S137. The findings reveal how these modifications impact the structural plasticity of dendritic spines, providing insights into neuronal function and plasticity (Cornelius J et al., 2023).

  • A structural model of the profilin-formin pacemaker system for actin filament elongation.: This paper presents a structural model involving poly-L-proline regions within the profilin-formin complex, which acts as a pacemaker for actin filament elongation. The study offers a detailed understanding of the molecular mechanisms driving actin dynamics and cellular movement (Schutt CE et al., 2022).

Ações bioquímicas/fisiológicas

Poly-L-Proline is an antigenic homopolymer.

Nota de análise

Molecular weight based on viscosity.

Outras notas

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)


Certificados de análise (COA)

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Sigma-Aldrich

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L-Proline from non-animal source, meets EP, USP testing specifications, suitable for cell culture

Sigma-Aldrich

P5607

L-Proline

Bindu Ambaru et al.
Molecular and biochemical parasitology, 238, 111280-111280 (2020-05-15)
Profilins are the key regulators of actin dynamics in all eukaryotic cells. However, little information is available on their biochemical properties and functions in kinetoplastids, such as Trypanosoma and Leishmania. We show here that Leishmania parasites express only one homolog
Nicholas Stephane Caron et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(36), 14610-14615 (2013-07-31)
Huntington disease (HD) is a neurodegenerative disorder caused by a CAG expansion within the huntingtin gene that encodes a polymorphic glutamine tract at the amino terminus of the huntingtin protein. HD is one of nine polyglutamine expansion diseases. The clinical
Alexander A Morgan et al.
PloS one, 8(1), e53785-e53785 (2013-02-02)
Proline is an anomalous amino acid. Its nitrogen atom is covalently locked within a ring, thus it is the only proteinogenic amino acid with a constrained phi angle. Sequences of three consecutive prolines can fold into polyproline helices, structures that
Yolanda Pérez et al.
Scientific reports, 3, 1295-1295 (2013-02-19)
c-Src is a non-receptor tyrosine kinase involved in numerous signal transduction pathways. The kinase, SH3 and SH2 domains of c-Src are attached to the membrane-anchoring SH4 domain through the flexible Unique domain. Here we show intra- and intermolecular interactions involving
Christopher J Woolstenhulme et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(10), E878-E887 (2013-02-23)
Although the ribosome is a very general catalyst, it cannot synthesize all protein sequences equally well. For example, ribosomes stall on the secretion monitor (SecM) leader peptide to regulate expression of a downstream gene. Using a genetic selection in Escherichia

Artigos

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