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P118

Sigma-Aldrich

Phaclofen

solid

Sinônimo(s):

3-Amino-2-(4-chlorophenyl)propanephosphonic acid

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5 MG
R$ 1.726,00
25 MG
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100 MG
R$ 19.883,00

About This Item

Fórmula empírica (Notação de Hill):
C9H13ClNO3P
Número CAS:
114012-12-3
Peso molecular:
249.63
Número MDL:
MFCD00069328
Código UNSPSC:
12352200
ID de substância PubChem:
24278189
NACRES:
NA.32

R$ 1.726,00

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Formulário

solid

Impurezas

≥97% (NMR)

cor

white

solubilidade

0.1 M HCl: 13.3 mg/mL
methanol: 19.3 mg/mL
DMSO: insoluble

cadeia de caracteres SMILES

NCC(CP(O)(O)=O)c1ccc(Cl)cc1

InChI

1S/C9H13ClNO3P/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H2,12,13,14)

chave InChI

VSGNGLJPOGUDON-UHFFFAOYSA-N

Informações sobre genes

human ... GABBR1(2550) , GABBR2(9568)

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Descrição geral

Phaclofen is a phosphonic acid derivative of baclofen.[1]

Aplicação

Phaclofen has been used to block GABAB receptor.[2]

Ações bioquímicas/fisiológicas

Phaclofen plays a vital role in identifying the physiological importance of central and peripheral bicuculline-insensitive receptors with which GABA and (−) baclofen interact.[1] Phaclofen acts as a GABAB receptor antagonist. Phaclofen has an ability to reversibly block the late, bicuculline resistant, K+ dependent inhibitory postsynaptic potential (IPSP) logged in projection cells of the cat and rat dorsal lateral geniculate nucleus and in rat hippocampal CA1 pyramidal neurons.[3]

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
042M4605V
066K4603
084H39003
084H39002
084H39001

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Sigma-Aldrich

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Aconitine

P Dutar et al.
Nature, 332(6160), 156-158 (1988-03-10)
The role of GABA in synaptic transmission in the mammalian central nervous system is more firmly established than for any other neurotransmitter. With virtually every neuron studied, the synaptic action of GABA is mediated by bicuculline-sensitive GABAA receptors which selectively
Effat Ramshini et al.
International journal of preventive medicine, 4(2), 158-164 (2013-04-02)
There is only little information about the effects of GABA receptors agonist and antagonist on morphine self-administration. Present study was designed to assess role of GABAB receptors in the regulation of morphine-reinforced self-administration. THIS STUDY WAS PERFORMED IN FOUR GROUPS
Kazuo Kunisawa et al.
European journal of pharmacology, 796, 122-130 (2016-12-13)
GABA mediated neuronal system regulates hippocampus-dependent memory and stress responses by controlling plasticity and neuronal excitability. Here, we demonstrate that betaine ameliorates water-immersion restraint stress (WIRS)-induced memory impairments. This improvement was inhibited by a betaine/GABA transporter-1 (GABA transporter-2: GAT2) inhibitor
Christof Geigerseder et al.
Reproductive biology and endocrinology : RB&E, 2, 13-13 (2004-03-26)
The neurotransmitter gamma-aminobutyric acid (GABA) and subtypes of GABA receptors were recently identified in adult testes. Since adult Leydig cells possess both the GABA biosynthetic enzyme glutamate decarboxylase (GAD), as well as GABA(A) and GABA(B) receptors, it is possible that
Makoto Nishiyama et al.
Frontiers in synaptic neuroscience, 2, 22-22 (2010-01-01)
GABAergic interneuronal network activities in the hippocampus control a variety of neural functions, including learning and memory, by regulating θ and γ oscillations. How these GABAergic activities at pre- and postsynaptic sites of hippocampal CA1 pyramidal cells differentially contribute to
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