P0869
Monoclonal Anti-Peroxisome Proliferator Activated Receptor α antibody produced in mouse
~1 mg/mL, clone 3B6/PPAR, purified immunoglobulin, buffered aqueous solution
Sinônimo(s):
Anti-PPARα
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100 μG
R$ 4.247,00
R$ 4.247,00
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100 μG
R$ 4.247,00
About This Item
R$ 4.247,00
Check Cart for Availability
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
3B6/PPAR, monoclonal
Formulário
buffered aqueous solution
reatividade de espécies
mouse, rat, human
concentração
~1 mg/mL
técnica(s)
western blot: 2-5 μg/mL using human, mouse and rat
Isotipo
IgG2b
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... PPARA(5465)
mouse ... Ppara(19013)
rat ... Ppara(25747)
Descrição geral
Peroxisome proliferator-activated receptors (PPARs) are a group of closely related nuclear receptors. Three PPAR isotypes have been identified: α,β (also called NUC1) and γ. PPARa mRNA is expressed most in brown adipose tissue, heart, liver and kidney in rats. The gene encoding PPARα is localized on human chromosome 22q12-q13.1 and rat chromosome 7q34.
Imunogênio
purified recombinant PPARα protein.
Ações bioquímicas/fisiológicas
Peroxisome proliferator-activated receptors (PPARs) may be involved in chronic diseases such as diabetes, obesity, atherosclerosis and cancer. PPARα has a protective function in fatty acids overload associated tubular injury. The enzyme also has a role in fatty acid oxidation and metabolism.
forma física
Solution in phosphate buffered saline containing 1 mg/ml bovine serum albumin and 0.05% sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Fenofibrate, a PPAR? agonist, protect proximal tubular cells from albumin-bound fatty acids induced apoptosis via the activation of NF-kB
Nan Zuo
International Journal of Clinical and Experimental Pathology, 8(9), 10653?10661-10653?10661 (2015)
Maria L R Hughes et al.
The Journal of biological chemistry, 290(22), 13895-13906 (2015-04-08)
Nuclear hormone receptors (NHRs) regulate the expression of proteins that control aspects of reproduction, development and metabolism, and are major therapeutic targets. However, NHRs are ubiquitous and participate in multiple physiological processes. Drugs that act at NHRs are therefore commonly
PPARs: molecular targets in the pharmacogenomics era
Prague Medical Report, 223-236 (2004)
Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism*
Be?atrice Desvergne and Walter Wahli
Endocrine Reviews, 20(5), 649?688-649?688 (1999)
C W Park et al.
Kidney international, 69(9), 1511-1517 (2006-05-05)
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a member of the ligand-activated nuclear receptor superfamily, and plays an important role in lipid metabolism and glucose homeostasis. The purpose of this study is to determine whether the activation of PPARalpha by fenofbrate
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