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O2260

Sigma-Aldrich

Mouse Osteopontin

recombinant, expressed in NSO cells, powder, suitable for cell culture

Sinônimo(s):

Bone Sialoprotein-1, Early T Lymphocyte Activation Protein-1 (ETA-1), OPN, Secreted Phosphoprotein 1 (Spp1)

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About This Item

Número MDL:
MFCD03100698
Código UNSPSC:
12352202
NACRES:
NA.32

product name

Osteopontin from mouse, >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

fonte biológica

mouse

Nível de qualidade

100

recombinante

expressed in NSO cells

esterilidade

sterile

Ensaio

>95% (SDS-PAGE)

forma

lyophilized powder

peso molecular

30 kDa by SDS-PAGE (reducing)
 65 kDa by SDS-PAGE (reducing) (doublet)

embalagem

pkg of 50 μg

técnica(s)

cell culture | mammalian: suitable

Impurezas

endotoxin, tested

nº de adesão UniProt

P10923

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

Informações sobre genes

mouse ... Spp1(20750)

Categorias relacionadas

Aplicação

Osteopontin from mouse has been used:
  • to study its role in a mouse model of preterm brain injury
  • as a positive control to analyze the relationship between the vascular calcification process and osteopontin (OPN) overexpression in the neointima of atherosclerotic plaques
  • to study its interaction on the crystal growth process of hydroxyapatite in agarose hydrogels

Ações bioquímicas/fisiológicas

Osteopontin (OPN) is a secreted, highly acidic, calcium binding, phosphorylated glycoprotein that is chemotactic for macrophages, smooth muscle cells, endothelial cells and glial cells. In activated macrophages, OPN inhibits nitric oxide production and cytotoxicity. Human, mouse, rat, pig and bovine OPN share 40% amino acid sequence identity.

forma física

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.

Nota de análise

The biological activity is measured by its ability to mediate 293 cell adhesion.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Osteopontin upregulation in atherogenesis is associated with cellular oxidative stress triggered by the activation of scavenger receptors
Jimenez CAE, et al.
Archives of Medical Research, 43(2), 102-111 (2012)
Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival
Denhardt DT, et al.
The Journal of Clinical Investigation, 107(9), 1055-1061 (2001)
The effect of osteopontin and osteopontin-derived peptides on preterm brain injury
Albertsson AM, et al.
Journal of Neuroinflammation, 11(1), 197-197 (2014)
Effect of osteopontin, chondroitin sulfates (B, C), and human serum albumin on the crystallization behavior of hydroxyapatite in agarose and silica hydrogels
Jimenez CAE, et al.
Crystal Growth & Design, 8(4), 1335-1339 (2008)
Yunan Zhu et al.
Japanese journal of infectious diseases, 68(6), 467-473 (2015-04-14)
The level of osteopontin (OPN) increases during bacterial lung infection. However, the OPN level in virus-induced lung injury is unclear, and the relationship between the hyer-production of OPN and lung injury remains to be thoroughly understood. Therefore, we sought to
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