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N5770

Sigma-Aldrich

Nalmefene

Sinônimo(s):

(5α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol

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About This Item

Fórmula empírica (Notação de Hill):
C21H25NO3
Número CAS:
55096-26-9
Peso molecular:
339.43
Número MDL:
MFCD00133650
Código UNSPSC:
12352200
ID de substância PubChem:
24897753

forma

solid

originador

Baxter

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=C)CC[C@@]35O)CC6CC6

InChI

1S/C21H25NO3/c1-12-6-7-21(24)16-10-14-4-5-15(23)18-17(14)20(21,19(12)25-18)8-9-22(16)11-13-2-3-13/h4-5,13,16,19,23-24H,1-3,6-11H2/t16-,19+,20+,21-/m1/s1

chave InChI

WJBLNOPPDWQMCH-MBPVOVBZSA-N

Informações sobre genes

human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988)
rat ... Oprd1(24613) , Oprm1(25601)

Ações bioquímicas/fisiológicas

Nonselective opioid receptor antagonist.

Características e benefícios

This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

Skull and crossbonesEnvironment
GHS06,GHS09

Palavra indicadora

Danger

Frases de perigo

H301,H336,H410

Classificações de perigo

Acute Tox. 3 Oral - Aquatic Chronic 1 - STOT SE 3

Órgãos-alvo

Central nervous system

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Hong-liang Wang et al.
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 22(6), 351-353 (2010-07-03)
To study the effect of nalmefene in treatment of patients with septic shock. Twenty patients, suffering from septic shock, admitted to the intensive care unit (ICU) from December, 2008 to June, 2009, were randomly divided into treatment group and control
Jon E Grant et al.
Psychopharmacology, 200(4), 521-527 (2008-06-27)
Although opiate antagonists have shown promise in the treatment of pathological gambling (PG), individual responses vary. No studies have systematically examined predictors of medication treatment outcome in PG. Understanding clinical variables related to treatment outcome should help generate treatment algorithms
Adrian W R Serohijos et al.
Structure (London, England : 1993), 19(11), 1683-1690 (2011-11-15)
Opioids that stimulate the μ-opioid receptor (MOR1) are the most frequently prescribed and effective analgesics. Here we present a structural model of MOR1. Molecular dynamics simulations show a ligand-dependent increase in the conformational flexibility of the third intracellular loop that
J A Culpepper-Morgan et al.
Life sciences, 56(14), 1187-1192 (1995-01-01)
Kappa(kappa) opioid agonists slow gastrointestinal transit in the guinea pig and the mouse but not the rat. Opioid antagonists naloxone and naltrexone are mu (mu) preferring, while the antagonist nalmefene has more kappa binding activity. When administered orally, the specific
Maryam Rezazadeh et al.
Journal of chromatography. A, 1262, 214-218 (2012-09-25)
In the present work, pulsed electromembrane extraction (PEME) is introduced for the first time as an efficient and inexpensive method for the extraction of ionizable compounds from different matrices. The setup proposed for electromembrane extraction (EME) provides a very stable
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