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N4766

Sigma-Aldrich

N-Nitroso-N-methylurea

Bulk package

Sinônimo(s):

MNU, N-Methyl-N-nitrosourea

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About This Item

Fórmula empírica (Notação de Hill):
C2H5N3O2
Número CAS:
684-93-5
Peso molecular:
103.08
Número MDL:
MFCD00014794
Código UNSPSC:
12352200
ID de substância PubChem:
24897712

forma

solid

contém

aqueous acetic acid as stabilizer

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CN(N=O)C(N)=O

InChI

1S/C2H5N3O2/c1-5(4-7)2(3)6/h1H3,(H2,3,6)

chave InChI

ZRKWMRDKSOPRRS-UHFFFAOYSA-N

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Ações bioquímicas/fisiológicas

DNA alkylating agent that is carcinogenic in many animal species. Although it can induce benign and malignant tumors in most organs, MNU is most often used to model mammary tumor initiation and progression.

Embalagem

Weight on dry basis.

Palavra indicadora

Danger

Frases de perigo

H228,H301,H350,H360

Declarações de precaução

P201 - P210 - P301 + P310 + P330

Classificações de perigo

Acute Tox. 3 Oral - Carc. 1B - Flam. Sol. 2 - Repr. 1B

Código de classe de armazenamento

4.1B - Flammable solid hazardous materials

Classe de risco de água (WGK)

WGK 1

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges

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Marzena Kurowska et al.
Mutation research, 738-739, 52-70 (2012-10-23)
We present studies aimed at determining the types and frequencies of mutations induced in the barley genome after treatment with chemical (N-methyl-N-nitrosourea, MNU) and physical (gamma rays) mutagens. We created M(2) populations of a doubled haploid line and used them
Yuan-Yuan Chen et al.
Experimental eye research, 121, 102-113 (2014-02-11)
Mouse retinal degeneration models have been investigated for many years in the hope of understanding the mechanism of photoreceptor cell death. N -methyl- N -nitrosourea (MNU) has been previously shown to induce outer retinal degeneration in mice. After MNU was
Kawiya Sintara et al.
Journal of biomedicine & biotechnology, 2012, 915380-915380 (2012-06-13)
To determine effects of curcumin on N-methyl-N-nitrosourea (MNU) and saturated sodium chloride (s-NaCl)-induced gastric cancer in rats. Male Wistar rats were divided into 5 groups: control (CO), control supplemented with 200 mg/kg curcumin (CC), MNU + s-NaCl, MNU + s-NaCl supplemented with 200 mg/kg curcumin daily
Yong Soon Chun et al.
Carcinogenesis, 33(11), 2242-2249 (2012-07-27)
Multiple lines of evidence support a role for curcumin in cancer chemoprevention. Nonetheless, despite its reported efficacy and safety profile, clinical translation of curcumin has been hampered by low oral bioavailability, requiring infeasible 'mega' doses for achieving detectable tissue levels.
Weiqin Jiang et al.
Cancer research, 72(15), 3795-3806 (2012-06-02)
An increased ratio of dietary n-3 relative to n-6 fatty acids has been shown to inhibit the development of mammary cancer in animal models. However, the molecular mechanisms by which n-3 fatty acids affect tumor growth remain unknown. Here, we
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