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N144

Sigma-Aldrich

Nitrendipine

>95%, powder

Sinônimo(s):

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester

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About This Item

Fórmula empírica (Notação de Hill):
C18H20N2O6
Número CAS:
39562-70-4
Peso molecular:
360.36
Número CE:
254-513-1
Número MDL:
MFCD00082255
Código UNSPSC:
12352200
ID de substância PubChem:
24277857
NACRES:
NA.77

Nível de qualidade

200

Ensaio

>95%

forma

powder

cor

yellow to green

solubilidade

methanol: 15 mg/mL
DMSO: 17.5 mg/mL
H2O: insoluble

cadeia de caracteres SMILES

CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC

InChI

1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3

chave InChI

PVHUJELLJLJGLN-UHFFFAOYSA-N

Informações sobre genes

human ... ADORA3(140) , CACNG1(786) , KCNH1(3756) , TTR(7276)
rat ... Adora1(29290) , Adora2a(25369)

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Ações bioquímicas/fisiológicas

Ca2+ channel blocker; anti-hypertensive.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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Annik Bergeron et al.
Bioanalysis, 4(8), 897-908 (2012-04-27)
In the past several years, the impact of changing counter ions while keeping the same anticoagulant in bioanalytical LC-MS/MS methods has become a highly discussed topic. In order to confirm that there is no impact from counter ions, matrix effect
Jian X Wu et al.
International journal of pharmaceutics, 433(1-2), 60-70 (2012-05-09)
This study focuses on the development of an automated image analysis method to extract information on nucleation and crystal growth from polarized light micrographs. Using the developed image analysis method, four parameters related to nucleation and crystal growth could be
Felix Steger et al.
Radiation oncology (London, England), 7, 212-212 (2012-12-18)
5-Fluorouracil (5-FU) is an antimetabolite, which is frequently used as chemotherapeutic agent for combined chemoradiotherapy. The purpose of this study was to present the clinical course of three patients who developed severe cardiac toxicity by 5-FU and to give a
Dengning Xia et al.
Pharmaceutical research, 29(1), 158-169 (2011-07-13)
To investigate anti-solvent crystallization and growth mechanism of nitrendipine spherical crystals in an aqueous solution containing polymeric additives. Size and shape of crystals were investigated using laser diffractometry, optical microscopy and scanning electron microscopy (SEM). Crystalline form was determined by
Peng Quan et al.
AAPS PharmSciTech, 12(4), 1136-1143 (2011-09-06)
The present investigation was undertaken with the objective of developing a solid formulation containing nitrendipine nanocrystals for oral delivery. Nitrendipine nanocrystals were prepared using a tandem precipitation-homogenization process. Then, spray drying, a cost-effective method very popular in industrial situations, was
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