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Key Documents

N1040

Sigma-Aldrich

N1-(7-Nitro-2,1,3-benzoxadiazol-4-yl)-N1,N2,N2-tris(2-pyridinylmethyl)-1,2-ethanediamine

for fluorescence

Sinônimo(s):

N-(2-(Bis((pyridin-2-yl)methyl)amino)ethyl)-7-nitro-N-((pyridin-2-yl)methyl)benzo[c][1,2,5]oxadiazole-4-amine, NBD-TPEA

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About This Item

Fórmula empírica (Notação de Hill):
C26H24N8O3
Número CAS:
Peso molecular:
496.52
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:

grau

for fluorescence

Ensaio

≥95%

forma

solid

fluorescência

λex 470 nm; λem 534 nm

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[O-][N+](=O)c1ccc(N(CCN(Cc2ccccn2)Cc3ccccn3)Cc4ccccn4)c5nonc15

InChI

1S/C26H24N8O3/c35-34(36)24-11-10-23(25-26(24)31-37-30-25)33(19-22-9-3-6-14-29-22)16-15-32(17-20-7-1-4-12-27-20)18-21-8-2-5-13-28-21/h1-14H,15-19H2

chave InChI

WBROPDACWHVGSC-UHFFFAOYSA-N

Aplicação

N1-(7-Nitro-2,1,3-benzoxadiazol-4-yl)-N1,N2,N2-tris(2-pyridinylmethyl)-1,2-ethanediamine has a high sensitivity for zinc ions. Using fluorescent detection, a linear responsive is observed for Zn2+ con­cen­trations in the range of 1-10 μM. It has good selectivity for Zn2+ in the presence of competing metal ions, such as Ca2+, Mg2+, Fe2+, Fe3+, and Mn2+, and has been used in vivo to determine Zn2+ concentration in pancreatic β cells and zebra fish larvae.

Pictogramas

Skull and crossbones

Palavra indicadora

Danger

Frases de perigo

Classificações de perigo

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Sandip Nathani et al.
Journal of fluorescence, 30(6), 1553-1565 (2020-09-19)
Zinc is essential for growth and development of all living organisms, especially human being. Deficiency of micronutrients like zinc and iron has been linked to the manifestation of hidden hunger. Therefore, it is imperative that development of some rapid screening
Nabil Hanna et al.
mBio, 12(1) (2021-02-04)
Macrophages use diverse strategies to restrict intracellular pathogens, including either depriving the bacteria of (micro)nutrients such as transition metals or intoxicating them via metal accumulation. Little is known about the chemical warfare between Mycobacterium marinum, a close relative of Mycobacterium
Tianke Zhang et al.
International journal of nanomedicine, 15, 1457-1468 (2020-03-19)
Zinc oxide nanoparticles (nZnO) have been widely used in the medicine field. Numerous mechanistic studies for nZnO's anticancer effects are merely performed under high concentration exposure. However, possible anticancer mechanisms of epigenetic dysregulation induced by low doses of nZnO are
Caroline Barisch et al.
Journal of cell science, 131(23) (2018-11-09)
Professional phagocytes have developed an extensive repertoire of autonomous immunity strategies to ensure killing of bacteria. Besides phagosome acidification and the generation of reactive oxygen species, deprivation of nutrients and the lumenal accumulation of toxic metals are essential to kill

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