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M9651

Sigma-Aldrich

Maprotiline hydrochloride

>99% (HPLC), powder

Sinônimo(s):

9-(γ-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C20H23N · HCl
Número CAS:
10347-81-6
Peso molecular:
313.86
Número CE:
233-758-8
Número MDL:
MFCD00079464
Código UNSPSC:
12352200
ID de substância PubChem:
24278576
NACRES:
NA.77

Ensaio

>99% (HPLC)

forma

powder

cor

white

solubilidade

H2O: 50 mg/mL

originador

Novartis

cadeia de caracteres SMILES

Cl.CNCCCC12CCC(c3ccccc13)c4ccccc24

InChI

1S/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H

chave InChI

NZDMFGKECODQRY-UHFFFAOYSA-N

Informações sobre genes

human ... SLC6A2(6530)

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Aplicação

Maprotiline hydrochloride has been used as a inhibitor of norepinephrine uptake to study its effects on arresting L3055 cell proliferation.

Ações bioquímicas/fisiológicas

Maprotiline is a tetracyclic agent. It possesses inhibitory effects against the uptake of norepinephrine by nerve cells. Maprotiline exhibits anti-depressant and sedative activity.

Características e benefícios

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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E Hösli et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 13(8), 897-908 (1995-12-01)
Autoradiographic studies were made on the uptake of 3H-noradrenaline and 3H-serotonin in explant cultures and primary astrocyte cultures from various regions of rat central nervous system (cortex, cerebellum, locus coeruleus, nucleus raphé, spinal cord). In explant cultures from locus coeruleus
The serotonin transporter (SLC6A4) is present in B-cell clones of diverse malignant origin: probing a potential antitumor target for psychotropics
Meredith E J, et al.
Faseb Journal, 19(9), 1187-1189 (2005)
Chemistry, pharmacology, pharmacokinetics, adverse effects, and efficacy of the antidepressant maprotiline hydrochloride
Wells B G and Gelenberg A J
Pharmacotherapy, 1(2), 121-138 (1981)
Murat Pinar et al.
Progress in neuro-psychopharmacology & biological psychiatry, 32(1), 135-139 (2007-09-11)
Agents such as clozapine, olanzapine and mirtazapine frequently trigger an increase in body weight. Though the mechanisms have not been thoroughly clarified, recent studies indicate a role for ghrelin in regulation of appetite and weight gain. We investigated the relation
Lynette Hui-Wen Lee et al.
The international journal of neuropsychopharmacology, 12(7), 953-964 (2009-02-11)
Recently, there has been considerable interest in a possible link between changes in brain polyunsaturated fatty acids, neural membrane phospholipid degradation, serotonergic neurotransmission, and depression. The present study aims to examine effects of antidepressants on lipids in different regions of
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