M9441
Microsomes from Liver, Pooled
from mouse(CD-1), male
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About This Item
Código UNSPSC:
12161501
NACRES:
NA.47
Produtos recomendados
fonte biológica
mouse (CD-1)
Nível de qualidade
forma
liquid
embalagem
vial of ~10 mg
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
mouse ... Mgst1(56615)
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Descrição geral
Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA).
Aplicação
Microsomes from Liver, Pooled has been also been used to study the metabolic stability of antitumor agents and tunicamycin.
Microsomes from Liver, Pooled has been used in cell survival and mutation assays in Escherichia coli.
Ações bioquímicas/fisiológicas
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
Microsomes might act as cell organelles and are actively involved in protein synthesis. Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids. Murine liver microsomes plays a crucial role in degradation of small antimicrobial β2,2-amino acid derivatives.
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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