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M8948

Sigma-Aldrich

Monoclonal Anti-Myocardin antibody produced in mouse

~2.0 mg/mL, clone MCR54, purified immunoglobulin

Sinônimo(s):

Anti-MYCD, Anti-MYOCD

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

mouse

conjugado

unconjugated

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

MCR54, monoclonal

forma

buffered aqueous solution

peso molecular

antigen ~150 kDa

reatividade de espécies

human

embalagem

antibody small pack of 25 μL

concentração

~2.0 mg/mL

técnica(s)

western blot: 2.5-5 μg/mL using HEK-293T cells overexpressing myocardin

Isotipo

IgG2b

nº de adesão UniProt

Q8IZQ8

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... MYOCD(93649)

Descrição geral

Monoclonal Anti-Myocardin (mouse IgG2b isotype) is derived from the hybridoma MCR54 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human myocardin. Myocardin (MYOCD) is a transcriptional coactivator.
Myocardin (MYOCD) is expressed in the muscles and cardiomyocytes. It is a co-transcriptional factor.

Aplicação

Monoclonal Anti-Myocardin antibody produced in mouse has been used in western blot analysisimmunofluorescence.

Ações bioquímicas/fisiológicas

Myocardin (MYOCD) takes part in the differentiation of vascular smooth muscle cells (VSMC). It is a co-factor of serum response factor (SRF) and regulates the activation of those genes which are dependent on SRF. MYOCD forms a complex with SRF on DNA.
Myocardin is a smooth and cardiac muscle-specific transcriptional coactivator of serum response factor (SRF). It regulates the expression of a set of cardiac and smooth muscle-specific genes. Myocardin was implicated in the pathogenesis of atherosclerosis, Alzheimer′s disease, and malignant transformation.

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 2

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Myocardin in biology and disease
Miano JM
Journal of biomedical research, 29(1), 3-3 (2015)
Fibroblast growth factor 12 is a novel regulator of vascular smooth muscle cell plasticity and fate
Song SH, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 36(9), 1928-1936 (2016)
The serum response factor coactivator myocardin is required for vascular smooth muscle development
Li S, et al.
Proceedings of the National Academy of Sciences of the USA, 100(16), 9366-9370 (2003)
Pavneet Singh et al.
PloS one, 9(11), e112120-e112120 (2014-11-11)
De-differentiation of vascular smooth muscle cells (VSMCs) plays a critical role in the development of atherosclerosis, a chronic inflammatory disease involving various cytokines such as tumor necrosis factor-α (TNFα). Myocardin is a co-factor of serum response factor (SRF) and is
Amarnath Talasila et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(10), 2355-2365 (2013-07-05)
Myocardin, a potent transcriptional coactivator of serum response factor, is involved in vascular development and promotes a contractile smooth muscle phenotype. Myocardin levels are reduced during vascular injury, in association with phenotypic switching of smooth muscle cells (SMCs). However, the
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