M4890
β2-Microglobulin from human urine
≥98% (SDS-PAGE), lyophilized powder
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About This Item
Produtos recomendados
fonte biológica
human urine
Nível de qualidade
Ensaio
≥98% (SDS-PAGE)
forma
lyophilized powder
peso molecular
11.6 kDa
nº de adesão UniProt
temperatura de armazenamento
−20°C
Informações sobre genes
human ... B2M(567)
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Aplicação
β2-Microglobulin from human urine was used to test humoral CSF parameters in the differential diagnosis of hematologic CNS neoplasia. It was also used in the identification of CTL epitopes in hepatitis C virus by a genome-wide computational scanning and a rational design of peptide vaccine.
Ações bioquímicas/fisiológicas
β2 microglobulin (β2-M) is a polypeptide that associates with the heavy chain of class I major histocompatibility complex (MHC) antigens on the cell surface. The interaction is dynamic and plays a critical role in the stability of the MHC antigens and their ability to present peptide antigens in CD8+ cells. A transient complex of MHC heavy chain and β2-M is known to be assembled into the TAP molecule (transporter associated with antigen processing) through interactions with a number of chaperones. Binding of processed peptide releases the Class I-β2-M complex to the cell surface. Absence of binding leads to degradation in the proteasome.
Embalagem
Package size based on protein content.
Nota de preparo
Prepared by the method of Berggard and Bearn.
Exoneração de responsabilidade
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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E Pamer et al.
Annual review of immunology, 16, 323-358 (1998-05-23)
Classical class I molecules assemble in the endoplasmic reticulum (ER) with peptides mostly generated from cytosolic proteins by the proteasome. The activity of the proteasome can be modulated by a variety of accessory protein complexes. A subset of the proteasome
Toshie Mashiba et al.
Immunogenetics, 59(3), 197-209 (2007-01-17)
Developing a peptide-based vaccine for the highly variable hepatitis C virus (HCV) remains a challenging task. Variant viruses not only escape antigen presentation but also persist in a patient as quasi-species. Such variants are often antagonistic to the responding T
M Weller et al.
Acta neurologica Scandinavica, 86(2), 129-133 (1992-08-01)
Cerebrospinal fluid (CSF) and serum samples of 20 patients with central nervous system manifestations of hematological malignancies including primary cerebral lymphoma (n = 5) and disseminated non-Hodgkin lymphoma (n = 7) were examined for albumin, IgG, IgM, fibronectin, beta 2-microglobulin
Yusuke Kambe et al.
Journal of controlled release : official journal of the Controlled Release Society, 327, 8-18 (2020-08-04)
Metabolic pathways in the body are highly specific. Dysfunction of a metabolic pathway triggers the accumulation of its target substance. For example, kidney failure results in increased β2-microglobulin blood levels, causing dialysis-related amyloidosis. Previously, we proposed a novel therapeutic concept
Yusuke Kambe et al.
Biomaterials science, 9(16), 5551-5558 (2021-07-08)
Kidney dysfunction increases the blood levels of β2-microglobulin (β2-m), triggering dialysis-related amyloidosis. Previously, we developed a navigator molecule, consisting of a fusion protein of the N-terminal domain of apolipoprotein E (ApoE NTD) and the α3 domain of the major histocompatibility
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