M4074

Mometasone furoate

≥98% (HPLC)

• Sinônimo(s): (11β,16α)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione
• Fórmula empírica (Notação de Hill): C₂₇H₃₀Cl₂O₆
• Número CAS: 83919-23-7
• Peso molecular: 521.43
• Número MDL: MFCD00866003
• Código UNSPSC: 51111800
• ID de substância PubChem: 329817988
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• atividade óptica: [α]/D +50 to +60°, c = 0.5 in methanol
• cor: white to off-white
• solubilidade: DMSO: ≥20 mg/mL
• originador: Schering Plough
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c5ccco5)C(=O)CCl
• InChI: 1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1
• chave InChI: WOFMFGQZHJDGCX-ZULDAHANSA-N
• Informações sobre genes: human ... NR3C1(2908)

Descrição

Aplicação

Mometasone furoate has been used to study its effect on Leishmania major amastigotes.[1]

Ações bioquímicas/fisiológicas

Mometasone furoate is a 17-heterocyclic intranasal corticosteroid. It is effectively used as a first-line daily intranasal therapeutic for allergic rhinitis and nasal polyposis. Mometasone furoate is also used as an adjunct to anti-bacterials for treating acute rhinosinusitis.[2] In addition, it relieves the symptoms of asthma in both adults and adolescents by exhibiting a broad spectrum of anti-inflammatory properties.[3]

Mometasone furoate is an anti-inflammatory glucocorticoid.

Características e benefícios

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H360D
• Declarações de precaução: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classificações de perigo: Repr. 1B
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable