M2901
Molsidomine
Sinônimo(s):
N-(Ethoxycarbonyl)-3-(4-morpholino)sydnone imine, SIN-10
Faça loginpara ver os preços organizacionais e de contrato
About This Item
Fórmula empírica (Notação de Hill):
C9H14N4O4
Número CAS:
Peso molecular:
242.23
Número CE:
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:
NACRES:
NA.77
Produtos recomendados
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
CCOC(=O)N=C1O[N-][N+](=C1)N2CCOCC2
InChI
1S/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3/b10-8-
chave InChI
XLFWDASMENKTKL-NTMALXAHSA-N
Procurando produtos similares? Visita Guia de comparação de produtos
Aplicação
Molsidomine has been used as nitric oxide (NO)-releasing vasodilator to study the effect of NO on angiostatin production in aging rat kidneys.[1]
Ações bioquímicas/fisiológicas
Molsidomine is an effective vasodilator[2] and a long-lasting nitric oxide (NO) donor.[1] It is a pro-drug that is enzymatically decarboxylated to form 3-morpholinosydnone imine (SIN-1) in the liver. Molsidomine is used as an anti-anginal agent and possesses antioxidant properties. It may be used to treat cisplatin-induced oxidative stress in the liver tissue.[2] Molsidomine has also been used during angina pectoris, heart failure, and after myocardial infarction.[3]
Orally active, long acting vasodilator; antianginal; converted by the liver to the active metabolite, SIN-1
Escolha uma das versões mais recentes:
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Molsidomine
Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (2016)
R E Nitz et al.
Pharmacotherapy, 7(1), 28-37 (1987-01-01)
The long-acting antianginal drug molsidomine has been shown experimentally to reduce myocardial infarct size when administered prior to or after cardiac insult. This is due to several drug actions. Dilation of postcapillary capacitance vessels diminishes venous return, preload, heart dimensions
Daniel L Graham et al.
Free radical research, 46(7), 891-902 (2012-04-20)
The breakdown of lycopene in the presence of reactive oxygen and reactive nitrogen species has been studied in order to identify key in vitro intermediates. These compounds may in turn be produced as metabolites in the body and may have
Soichiro Akashi et al.
Biological & pharmaceutical bulletin, 35(7), 1105-1117 (2012-07-14)
Treatment of PC12 cells with fungus-derived alkaloid neoechinulin A for more than 12 h renders the cells resistant to subsequent superoxide (O₂⁻)/nitric oxide (NO) insults derived from 3-morpholinosydnonimine (SIN-1). However, the underlying mechanism(s) remains largely unclear. To elucidate the mechanism(s), we
Moumita Bose et al.
Free radical biology & medicine, 53(10), 1819-1828 (2012-09-19)
Heme proteins share the ability to detoxify reactive nitrogen intermediates (NO and peroxynitrite). But, to date, no heme-containing enzymatic defense against toxic reactive nitrogen intermediates has been discovered in Leishmania species. We have cloned, expressed, and characterized a pseudoperoxidase from
Active Filters
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica
