M2537

Mevastatin

≥98% (HPLC), powder or crystals

• Sinônimo(s): Compactin, ML-236B
• Fórmula empírica (Notação de Hill): C₂₃H₃₄O₅
• Número CAS: 73573-88-3
• Peso molecular: 390.51
• Beilstein: 1269441
• Número MDL: MFCD05662341
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278540
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Formulário: powder or crystals
• cor: white to light yellow
• pf: 151 °C
• solubilidade: ethanol: 25-26 mg/mL, clear, colorless
• espectro de atividade do antibiótico: neoplastics
• Modo de ação: enzyme | inhibits
• originador: Daiichi-Sankyo
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: [H][C@]12[C@H](CCC=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)[C@@H](C)CC
• InChI: 1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1
• chave InChI: AJLFOPYRIVGYMJ-INTXDZFKSA-N
• Informações sobre genes: human ... HMGCL(3155) , HMGCR(3156) ; rat ... Hmgcr(25675)

Descrição

Descrição geral

Chemical structure: statin

Mevastatin is a polyketide that belongs to the class of statins. It contains a hydroxy-hexahydronaphthalene ring.[1]

Aplicação

Mevastatin has been used:

• to analyze its effects on chronic lymphocytic leukemia (CLL) cells by cytotoxic assay[2]
• as a prenylation inhibitor to analyze its effects on human embryonic kidney (HEK) cells transfected with K-Ras[3]
• as a statin agent to study its anti-cancer effect on human breast cancer cells and glioblastoma in vitro[4]

Ações bioquímicas/fisiológicas

Mevastatin is a selective inhibitor of 3-hydroxy 3-methyl glutaryl coenzyme(A) reductase (HMG-CoA reductase), a major enzyme involved in cholesterol synthesis. It acts as a cholesterol-lowering agent. Mevastatin is obtained from various species of fungi.[1] It acts as an antiresorptive agent and has therapeutic effects to treat osteoporosis. Mevastatin inhibits bone resorption by triggering osteoclast apoptosis. It is also involved in the inhibition of prenylation of proteins such as Ras.[5] Mevastatin increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels by blocking the geranylgeranylation of transcription factor Rho.[6]

Características e benefícios

This compound was developed by Daiichi-Sankyo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)