SML0005

Cerivastatin sodium salt hydrate

≥98% (HPLC)

• Sinônimo(s): (3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic acid sodium salt hydrate, Rivastatin hydrate
• Fórmula empírica (Notação de Hill): C₂₆H₃₃FNNaO₅ · xH₂O
• Número CAS: 143201-11-0
• Peso molecular: 481.53 (anhydrous basis)
• Número MDL: MFCD20488047
• Código UNSPSC: 12352200
• ID de substância PubChem: 329825082
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• forma: powder
• atividade óptica: [α]/D +18 to +26° in ethanol
• condição de armazenamento: desiccated
• cor: white to tan
• solubilidade: H₂O: ≥5 mg/mL
• originador: Bayer
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O.[Na+].COCc1c(nc(C(C)C)c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c1-c2ccc(F)cc2)C(C)C
• InChI: 1S/C26H34FNO5.Na.H2O/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4;;/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32);;1H2/q;+1;/p-1/b11-10+;;/t19-,20-;;/m1../s1
• chave InChI: NJHMEKXCHXHQPP-PZLZTSNUSA-M

Descrição

Descrição geral

Cerivastatin sodium salt hydrate belongs to the statin class of lipid lowering agents. It helps in decreasing MAP kinase activation, blocking AP-1 (activator protein-1) and NF-kB (nuclear factor-kB ) binding activity, inhibiting inflammatory responses and ameliorated renal damage. It also lowers cholesterol. It is metabolized by cytochrome P450 (CYP)3A4 and (CYP)2C8. Cerivastatin sodium salt hydrate is linked to rhabdomyolysis.

Aplicação

Cerivastatin sodium salt hydrate has been used as a supplement in cell culture.

Cerivastatin sodium salt hydrate may be used in cell signaling studies.

Ações bioquímicas/fisiológicas

Accumulated macrophages in atherosclerotic plaques result in plaque rupture and thrombus formation. Cerivastatin suppresses the growth of macrophages and decreases the expression of matrix metalloproteinases and tissue factor molecules, thus reduces acute coronary events.

Cerivastatin sodium is an HMG-CoA reductase inhibitor. HMG-CoA is a key enzyme in the production of cholesterol.

Características e benefícios

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable