M152

2-(Methylthio)adenosine 5′-diphosphate trisodium salt hydrate

≥89% (HPLC), solid

• Sinônimo(s): 2-(Methylthio)adenosine 5′-trihydrogen diphosphate trisodium salt hydrate, 2-Methylthio-ADP trisodium salt hydrate
• Fórmula empírica (Notação de Hill): C₁₁H₁₄N₅Na₃O₁₀P₂S · xH₂O
• Número CAS: 475193-31-8
• Peso molecular: 539.24 (anhydrous basis)
• Número MDL: MFCD11044463
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278816

Propriedades

• Ensaio: ≥89% (HPLC)
• Formulário: solid
• condição de armazenamento: desiccated
• cor: white
• solubilidade: H₂O: >20 mg/mL
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O.[Na+].[Na+].[Na+].CSc1nc(N)c2ncn([C@@H]3O[C@H](COP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]3O)c2n1
• InChI: 1S/C11H17N5O10P2S.3Na.H2O/c1-29-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(25-10)2-24-28(22,23)26-27(19,20)21;;;;/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,23)(H2,12,14,15)(H2,19,20,21);;;;1H2/q;3*+1;/p-3/t4-,6-,7-,10-;;;;/m1..../s1
• chave InChI: JPTPEMXICPAWKJ-KWIZKVQNSA-K

Descrição

Ações bioquímicas/fisiológicas

2-Methylthio-ADP (2-ME-SADP) is a P2 purinoceptor agonist, which induces platelet aggregation and shape change and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1. Compared with ADP, 2-methylthio-ADP was 3-5 times as active as an aggregating agent and 150-200 times as active as an inhibitor of cyclic AMP accumulation. Purinergic signaling may be an important factor in TSP-1-mediated cell-matrix and cell-cell interactions such as those occurring during development and repair.

Características e benefícios

This compound is featured on the P2 Receptors: P2Y G-Protein Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Atenção

Hygroscopic, air sensitive

Informações de segurança

• Código de classe de armazenamento: 13 - Non Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)