J4644
Anti-phospho-JNK1/2 (pThr183/pTyr185) antibody produced in rabbit
affinity isolated antibody, buffered aqueous glycerol solution
Sinônimo(s):
Anti-phospho-SAPK (pTpY183/185), Anti-phospho-Stress Activated Protein Kinase (pTpY183/185), Anti-phospho-c-Jun N-terminal Kinase 1/2 (pTpY183/185)
Faça loginpara ver os preços organizacionais e de contrato
Selecione um tamanho
1 VIAL
R$ 6.112,00
R$ 6.112,00
Previsão de entrega em16 de abril de 2025
Um anticorpo recombinante, sem conservantes, está disponível para seu alvo. Tente ZRB1173
Selecione um tamanho
Alterar visualização
1 VIAL
R$ 6.112,00
About This Item
R$ 6.112,00
Previsão de entrega em16 de abril de 2025
Um anticorpo recombinante, sem conservantes, está disponível para seu alvo. Tente ZRB1173
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous glycerol solution
reatividade de espécies
rat, human
técnica(s)
immunocytochemistry: 1:250
immunofluorescence: 1:250
immunohistochemistry: Assay Dependent
western blot: 1:200-1:2000 (using human 293 cells treated with UV radiation)
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Informações sobre genes
human ... MAPK8(5599)
Descrição geral
c-Jun N-terminal kinase (JNK, SAPK) is an extensively studied memebr of the MAPK family of kinases and is critical in mediating the apoptotic signaling. There are three isoforms of JNK, JNK 1, 2 and 3. JNK 1 and 2 are ubiquitously expressed; JNK 3 is restricted to cardiac and neuronal tissues.
Imunogênio
synthetic peptide derived from a region of JNK1 & 2 that contains threonine183 and tyrosine185.
Aplicação
Anti-phospho-JNK1/2 (pThr183/pTyr185 ) antibody concentration is formulated to be used at the recommended dilutions by application.
Ações bioquímicas/fisiológicas
JNK (c-Jun N-terminal kinase) is phosphorylated by MAPK (mitogen activated protein kinase) kinases 4 and 7 at Thr183 and Tyr185, leading to its activation. It is however not clear as to which MAPKK phosphorylates which amino acid residue. The activation of JNK is highly regulated and is in response to the stress signals that the cell faces. JNK phosphorylates c-Jun, the most important member of the AP-1 transcription factor family that is involved in survival, apoptosis, proliferation and tumorigenesis. JNK also activates other transcription factors such as c-myc and p53. JNK is involved in the phosphorylation of proteins such as Bad, Bcl2 and Bim that result in the execution of apoptosis by release of cytochrome c from mitochondria.
Anti-phospho-JNK1/2 (SAPK) (pThr183/pTyr185 ) specifically recognizes the endogenous, active forms of JNK1 and 2 phosphorylated at threonine 183 and tyrosine 185.
Anti-phospho-JNK1/2 (SAPK) (pThr183/pTyr185 ) specifically recognizes the endogenous, active forms of JNK1 and 2 phosphorylated at threonine 183 and tyrosine 185.
forma física
Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 50% glycerol, 1% bovine serum albumin (BSA) (IgG and preservatives free) and 0.05% sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Não está encontrando o produto certo?
Experimente o nosso Ferramenta de seleção de produtos.
recomendado
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Escolha uma das versões mais recentes:
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Gaurav Verma et al.
Journal of cellular physiology, 227(5), 1791-1795 (2011-07-07)
Apoptosis or programmed cell death is an extremely coordinated phenomenon that involves the participation of a complex interacting crosstalk between the endoplasmic reticulum and mitochondria. This involves a series of signaling molecules like stress kinases, caspases, Bcl-2 family of proteins
Ksenya Cohen-Katsenelson et al.
The Biochemical journal, 439(3), 381-390 (2011-07-14)
JNK (c-Jun N-terminal kinase) is part of a MAPK (mitogen-activated protein kinase) signalling cascade. Scaffold proteins simultaneously associate with various components of the MAPK signalling pathway and play a crucial role in signal transmission and MAPK regulation. WDR62 (WD repeat
F Urano et al.
Science (New York, N.Y.), 287(5453), 664-666 (2000-01-29)
Malfolded proteins in the endoplasmic reticulum (ER) induce cellular stress and activate c-Jun amino-terminal kinases (JNKs or SAPKs). Mammalian homologs of yeast IRE1, which activate chaperone genes in response to ER stress, also activated JNK, and IRE1alpha-/- fibroblasts were impaired
Anning Lin et al.
Aging cell, 1(2), 112-116 (2003-07-29)
Age-associated changes in apoptotic rates have been observed in a number of different tissues. While the implications of these findings remain unclear, a better understanding of how apoptosis is regulated may further our understanding of the aging process. The role
Jing Liu et al.
Cell research, 15(1), 36-42 (2005-02-03)
JNK is a key regulator of many cellular events, including programmed cell death (apoptosis). In the absence of NF-kB activation, prolonged JNK activation contributes to TNF-a induced apoptosis. JNK is also essential for UV induced apoptosis. However, recent studies reveal
Active Filters
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica
