ID-8 is an inhibitor of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A).[1]
Ações bioquímicas/fisiológicas
ID-8 sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Stimulates proliferation at a steady rate (observed in serum-free media supplemented with 10 μM over a 30 day period).
Sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro.
Current molecular pharmacology, 9(3), 272-279 (2015-05-27)
Despite their high degree of identity and even higher homology, the two Kat3 transcriptional coactivators, CBP and p300, have distinct functions, particularly within the Wnt/β-catenin signaling cascade. ICG-001, by directly binding to CBP but not p300, inhibits CBP/β-catenin transcription and
The purpose of our study was to validate perfusion quantification in a low-perfused tissue by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with shared k-space sampling using a blood pool contrast agent. Perfusion measurements were performed in a total of seven
A High-Throughput Screen Identifies DYRK1A inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation
Monteiro M B, et al.
Journal of the American Society of Nephrology, ASN-2018040392 (2018)
Annals of translational medicine, 8(20), 1295-1295 (2020-11-20)
In Chinese herbal medicine, Tanshinone IIA (Tan-IIA) is one of the main compounds extracted from Salvia miltiorrhiza Bunge. Tan-IIA has been demonstrated to inhibit the growth of various tumors. However, the detailed molecular and cellular mechanisms of the antitumor effect
Molecular cancer therapeutics, 20(4), 716-725 (2021-02-05)
Ovarian cancer is a diverse class of tumors with very few effective treatment options and suboptimal response rates in early clinical studies using immunotherapies. Here we describe LY6/PLAUR domain containing 1 (LYPD1) as a novel target for therapeutic antibodies for
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