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I0531

Sigma-Aldrich

Interleukin-18 from rat

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

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About This Item

Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.32

fonte biológica

rat

Nível de qualidade

recombinante

expressed in E. coli

Ensaio

>97% (SDS-PAGE)

forma

lyophilized powder

potência

10-60 ng/mL ED50

peso molecular

predicted mol wt ~18.4 kDa

embalagem

pkg of 25 μg

Impurezas

endotoxin, tested

nº de adesão UniProt

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

Informações sobre genes

rat ... Il18(29197)

Ações bioquímicas/fisiológicas

Interleukin 18, also known as interferon-γ-inducing factor (IGIF) and IL-1γ, is a proinflammatory cytokine. It is an inducer of IFN-γ and Th1 (T cell helper type 1) responses (cell differentiation, cell-mediated cytotoxicity and inflammation). IL-18 induces the migration of microvascular endothelial cells.

forma física

Lyophilized from 20 mM Tris , 500 mM NaCl, 0.5 mM EDTA, 1 mM TCEP, 0.05% (w/v) PEG8000 pH 8.0 with 5% Trehalose,and 50 μg BSA per μg IL-18

Nota de análise

The biological activity is measured by its ability to induce mouse IFN-γ production by activated mouse T cells.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Regulatory toxicology and pharmacology : RTP, 69(3), 371-379 (2014-05-13)
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TL1A is a TNF-like cytokine which has been shown to co-stimulate TH1 and TH17 responses during chronic inflammation. The expression of this novel cytokine has been investigated in inflammatory disorders like rheumatoid arthritis and inflammatory bowel disease, but little is
M Dagenais et al.
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