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I8648

Sigma-Aldrich

Interleukin-15 human

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinônimo(s):

IL-15

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5 μG
R$ 2.064,00

R$ 2.064,00


Previsão de entrega em17 de abril de 2025



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5 μG
R$ 2.064,00

About This Item

Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.77

R$ 2.064,00


Previsão de entrega em17 de abril de 2025


fonte biológica

human

Nível de qualidade

recombinante

expressed in E. coli

Ensaio

>97% (SDS-PAGE)

Formulário

lyophilized powder

potência

0.2-4.0 ng/mL EC50

peso molecular

antigen predicted mol wt ~12.5 kDa

embalagem

pkg of 5 μg

técnica(s)

cell culture | mammalian: suitable

Impurezas

endotoxin, tested

nº de adesão UniProt

temperatura de armazenamento

−20°C

Informações sobre genes

human ... IL15(3600)

Ações bioquímicas/fisiológicas

IL-15 (interleukin 15) is a proinflammatory pleiotropic cytokine and is a connection between innate and adaptive immune responses. It participates in the proliferation, survival and activation of various lymphocytes lineages. IL-15 works by associating with a high affinity heterotrimeric receptor complex containing IL-15Rα, IL-2/15Rβ and IL-Rγ.[1][2][3] It is present in different forms, the soluble form, the hyper IL-15 formed by association between IL-15 receptor α chain and soluble cytokine, and the membrane bound isoform.[1]
Interleukin-15 was first isolated from the supernatant of a cultured simian kidney epithelial cell line.[4] The cDNA encodes a 162 amino acid precursor protein with a 48 amino acid signal peptide that is cleaved to yield a 114 amino acid mature protein. Human IL-15 shares sequence identity with simian (~97%) and murine (~73%). IL-15 competes for binding sites with IL-2, as both IL-2 and IL-15 stimulate the growth of cells through the IL-2 receptor.

forma física

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline, pH 7.4 with 50 μg bovine serum albumin per 1 μg as a carrier protein.

Nota de análise

Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The specific activity of Recombinant Human IL-15 is approximately 4.5 x 105 U/μg, which is calibrated against recombinant human IL-15 WHO International Standard (NIBSC code: 95/554).

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)


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Hua Wang et al.
Medical oncology (Northwood, London, England), 32(1), 370-370 (2014-11-28)
Interleukin-15 (IL-15) is a proinflammatory cytokine involved in the proliferation, survival, and activation of multiple lymphocyte lineages. However, the prognostic significance of IL-15 for extranodal NK/T cell lymphoma (ENKTL) has not been well established. We retrospectively analyzed 112 patients with
Alicia Santos Savio et al.
BMC musculoskeletal disorders, 16, 51-51 (2015-04-17)
Pro-inflammatory cytokines are directly implicated in the pathogenesis of Rheumatoid arthritis (RA). Variable clinical response to cytokine targeted therapies as TNFalpha and IL-6, strongly highlights the heterogeneity of inflammatory process in RA. Another cytokine, IL-15 has also been related to
Mario Bunse et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(11), 1983-1991 (2014-07-23)
Genetically modified T cells that express a transduced T cell receptor (TCR) α/β heterodimer in addition to their endogenous TCR are used in clinical studies to treat cancer. These cells express two TCR-α and two TCR-β chains that do not
K H Grabstein et al.
Science (New York, N.Y.), 264(5161), 965-968 (1994-05-13)
A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues
Jianan Zhu et al.
Frontiers in immunology, 13, 813218-813218 (2022-03-01)
Unexplained recurrent spontaneous abortion (URSA) is believed to be associated with impaired immunosuppression at the maternal-fetal interface, but the detailed molecular mechanism remains unclear. The ATP-adenosine metabolic pathway regulated by CD39/CD73 has recently been recognized to be important in immunosuppression.

Artigos

Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.

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