I0274
myo-Inositol Monophosphatase from bovine brain
lyophilized powder, 5-20 units/mg protein
Sinônimo(s):
myo-Inositol monophosphate phosphohydrolase
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About This Item
Número CAS:
Número MDL:
Código UNSPSC:
12352204
Produtos recomendados
forma
lyophilized powder
atividade específica
5-20 units/mg protein
composição
Protein, ~0.5% Bradford
temperatura de armazenamento
−20°C
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Aplicação
The enzyme plays a critical role in the recycling of inositol to phosphoinositides in the mammalian brain and participates in the phosphatidylinositol signaling pathway. It is inhibited non-competitively by Li+, which may be significant in the treatment of manic depression. The enzyme may help in identifying less toxic substitutes for lithium in manic depressive therapy.
Definição da unidade
One unit will form 1.0 μmole of phosphate from inositol 1-phosphate per min at pH 7.4 at 37°C.
forma física
Lyophilized powder containing HEPES buffer salts, pH 7.5, and stabilizer
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Svetlana Kalujnaia et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(10), 3981-3991 (2010-06-16)
This study investigated the expression and tissue distribution of inositol monophosphatase (IMPA1) and characterized its role in salinity adaptation in the eel. The coding sequence of eel IMPA1 was determined and confirmed to be orthologous to the mammalian gene/enzyme by
Christopher A Broberg et al.
Science (New York, N.Y.), 329(5999), 1660-1662 (2010-08-21)
The marine bacterium Vibrio parahaemolyticus causes gastroenteritis in humans and encodes the type III effector protein VPA0450, which contributes to host cell death caused by autophagy, cell rounding, and cell lysis. We found that VPA0450 is an inositol polyphosphate 5-phosphatase
Sudipta Bhattacharyya et al.
Biochimie, 94(3), 879-890 (2011-12-27)
Inositol monophosphatase (IMPase) family of proteins are Mg(2+) activated Li(+) inhibited class of ubiquitous enzymes with promiscuous substrate specificity. Herein, the molecular basis of IMPase substrate specificity is delineated by comparative crystal structural analysis of a Staphylococcal dual specific IMPase/NADP(H)
S J Pollack et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(13), 5766-5770 (1994-06-21)
myo-Inositol monophosphatase (myo-inositol-1-phosphate phosphohydrolase, EC 3.1.3.25) is an attractive target for mechanistic investigation due to its critical role in the phosphatidylinositol signaling pathway and the possible relevance of its inhibition by Li+ to manic depression therapy. The x-ray crystallographic structure
Livia Pasquali et al.
Behavioural pharmacology, 21(5-6), 473-492 (2010-08-12)
This is a short overview focusing on the biochemical interactions underlying the protective effects of lithium at the neuronal level. These include lithium modulation of autophagy, growth factors, excitotoxicity, and a variety of mechanisms underlying cell death, neurogenesis, and neuronal
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