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H3751

Sigma-Aldrich

D-Histidine

≥98% (TLC)

Sinônimo(s):

(R)-2-Amino-3-(4-imidazolyl)propionic acid, D-α-Amino-β-(4-imidazolyl)propionic acid

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About This Item

Fórmula empírica (Notação de Hill):
C6H9N3O2
Número CAS:
Peso molecular:
155.15
Beilstein:
84089
Número CE:
Número MDL:
Código UNSPSC:
12352209
eCl@ss:
32160406
ID de substância PubChem:
NACRES:
NA.26

Ensaio

≥98% (TLC)

forma

powder

cor

white

pf

280 °C

solubilidade

1 M HCl: soluble

aplicação(ões)

detection
peptide synthesis

cadeia de caracteres SMILES

N[C@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m1/s1

chave InChI

HNDVDQJCIGZPNO-RXMQYKEDSA-N

Informações sobre genes

human ... CA1(759) , CA2(760)

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Ações bioquímicas/fisiológicas

D-Histidine may be used in the design of peptide drugs, cationic peptides, such as analogues of carnosine. D-Histidine may also be used as a heavy metal sequestration agent.

Outras notas

Inactive isomer

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)


Certificados de análise (COA)

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L-Histidina ≥98% (HPLC)

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Supelco

73767

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D-Alanine ≥98% (HPLC)

Sigma-Aldrich

A7377

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Satoru Torii et al.
Journal of biochemistry, 149(2), 171-176 (2010-11-03)
Cobalt chloride (CoCl(2)) can mimic hypoxia in inducing hypoxia-inducible factor 1 (HIF-1). Several cultured cells were examined for susceptibility to CoCl(2) in DMEM, MEM and RPMI 1640 medium. Here we report that HIF-1α expression of mammalian cells by CoCl(2) was
Giulio Vistoli et al.
ChemMedChem, 4(6), 967-975 (2009-03-21)
Carnosine aryl derivatives as sequestering agents of RCS: Reactive carbonyl species (RCS) are cytotoxic mediators representing a novel drug target, as they are presumed to play a pathogenic role in several diseases. Carnosine is a selective RCS-sequestering agent, but is
Merita Murtola et al.
Chembiochem : a European journal of chemical biology, 11(18), 2606-2612 (2010-11-27)
Several different cationic nonapeptides have been synthesized and investigated with respect to how they can influence the thermal melting of 2'-O-methylRNA/RNA and DNA/DNA duplexes. Each peptide has a C-terminal L-phenylalanine unit and is otherwise uniformly composed of a sequence of
Marica Orioli et al.
ChemMedChem, 6(7), 1269-1282 (2011-06-03)
β-Alanyl-D-histidine (D-CAR, the enantiomer of the natural dipeptide carnosine) is a selective and potent sequestering agent of reactive carbonyl species (RCS) that is stable against carnosinase, but is poorly absorbed in the gastrointestinal tract. Herein we report a drug discovery
Brian T Wilhelm et al.
Nature protocols, 5(2), 255-266 (2010-02-06)
Next-generation sequencing technologies are revolutionizing genomics research. It is now possible to generate gigabase pairs of DNA sequence within a week without time-consuming cloning or massive infrastructure. This technology has recently been applied to the development of 'RNA-seq' techniques for

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