F5053
Flavin-Containing Monooxygenase-3, Microsomes human
recombinant, expressed in baculovirus infected insect cells, buffered aqueous solution
Sinônimo(s):
FMO-3
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R$ 7.417,00
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Previsão de entrega em28 de maio de 2025
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1 VIAL
R$ 7.417,00
About This Item
R$ 7.417,00
Previsão de entrega em28 de maio de 2025
Produtos recomendados
recombinante
expressed in baculovirus infected insect cells
Nível de qualidade
Formulário
buffered aqueous solution
peso molecular
55-60 kDa
embalagem
vial of 2.5 mg
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... FMO3(2328)
Descrição geral
Flavin-Containing Monooxygenase-3 (FMO3) is a member of the flavin-containing monooxygenase (FMO) family of enzymes. It is highly expressed in the human liver.[1]
Aplicação
FMO3 is the major human hepatic form.
Ações bioquímicas/fisiológicas
Flavin-Containing Monooxygenase-3 (FMO3) facilitates the oxidization of several drugs, chemicals, and xenobiotics.[2] Human FMO3 is also involved in the synthesis of N-oxide of trimethylamine (TMAO) from trimethylamine (TMA).[3] Mutations in the FMO3 gene are associated with trimethylaminuria or fish odor syndrome.[1][4] Deficiency of the FMO3 gene results in lower plasma TMAO levels, which may reduce the risk of developing atherosclerosis and thrombosis.[4]
forma física
Solution in 100 mM potassium phosphate buffer, pH 7.4
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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W Zhu et al.
Journal of thrombosis and haemostasis : JTH, 16(9), 1857-1872 (2018-07-08)
Essentials Microbe-dependent production of trimethylamine N-oxide (TMAO) contributes to thrombosis risk. The impact of host flavin monooxygenase 3 (FMO3) modulation on platelet function is unknown. Genetic manipulation of FMO3 in mice alters systemic TMAO levels and thrombosis potential. Genetic manipulation
Irfan M Hisamuddin et al.
Pharmacogenomics, 8(6), 635-643 (2007-06-15)
Flavin-containing monooxygenase 3 (FMO3) is a hepatic microsomal enzyme that oxidizes a host of drugs, xenobiotics and other chemicals. Numerous variants in the gene encoding FMO3 have been identified, some of which result in altered enzymatic activity and, consequently, altered
Chongliang Gao et al.
Scientific reports, 7(1), 14668-14668 (2017-11-09)
Human flavin-containing monooxygenase 3 (hFMO3) catalyses the oxygenation of a wide variety of compounds including drugs as well as dietary compounds. It is the major hepatic enzyme involved in the production of the N-oxide of trimethylamine (TMAO) and clinical studies
Robert R Reddy et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2239-2245 (2010-09-03)
The flavin-containing monooxygenase (FMO) family of enzymes oxygenates nucleophilic xenobiotics and endogenous substances. Human FMO3 and FMO5 are the predominant FMO forms in adult liver. These enzymes are naturally membrane-bound, and recombinant proteins are commercially available as microsomal preparations from
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