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E6627

Sigma-Aldrich

cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt

≥99% (capillary GC)

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About This Item

Fórmula linear:
CH3(CH2CH=CH)5(CH2)3CO2Na
Número CAS:
73167-03-0
Peso molecular:
324.43
Número MDL:
MFCD00079184
Código UNSPSC:
12352211
ID de substância PubChem:
24894631
NACRES:
NA.77

fonte biológica

synthetic (organic)

Nível de qualidade

200

Ensaio

≥99% (capillary GC)

forma

film or powder

cor

white to off-white

solubilidade

methanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[Na].CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

InChI

1S/C20H30O2.Na.H/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22;;/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22);;/b4-3-,7-6-,10-9-,13-12-,16-15-;;

chave InChI

TVEGTERCKGGVCJ-LIJGWLRISA-N

Informações sobre genes

human ... ALOX5(240)
mouse ... ALOX5(11689)
rat ... ALOX5(25290)

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Descrição geral

Eicosapentaenoic acid (EPA)/timnodonic acid is an omega-3 polyunsaturated fatty acid (PUFA). This long-chain fatty acid is mainly found in fish oil.

Aplicação

cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt has been used:
  • to study its effect on the pathology of lupus in drug-induced and spontaneous mouse models
  • to pretreat mouse alveolar macrophages to study the effect/relationship between amiodarone and eicosapentaenoic acid (EPA) concerning the cytokine release
  • to examine if pharmacological correction with EPA supplementation might restore autophagic flux and reduce renal lipotoxicity in mice

Ações bioquímicas/fisiológicas

Eicosapentaenoic acid (EPA) possesses anti-hyperglycemic, anti-oxidant, anti-hyperlipidemic, and anti-inflammatory properties. It aids in improving vasoreactivity. EPA is capable of suppressing vascular smooth muscle proliferation. It ameliorates pulmonary hypertension by preventing Fyn kinase activity. EPA exhibits a beneficial effect on lipid metabolism. It is used to treat hypercholesterolemia and atherosclerosis.
5-Lipoxygenase inhibitor; reduces thromboxane A2 production.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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Arachidonic acid from non-animal source, ≥98.5% (GC)

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Ácido linolênico ≥99%

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Arachidonic acid >95.0% (GC)

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Arachidonic acid

Lin Hai Kurahara et al.
Journal of molecular and cellular cardiology, 148, 50-62 (2020-09-06)
Pulmonary arterial hypertension (PAH) is a multifactorial disease characterized by pulmonary arterial vasoconstriction and remodeling. Src family tyrosine kinases, including Fyn, play critical roles in vascular remodeling via the inhibition of STAT3 signaling. EPA is known to inhibit Fyn kinase
Y Futamura
Japanese journal of pharmacology, 69(4), 335-341 (1995-12-01)
I studied the effect of amiodarone, a cationic amphiphilic drug, on the cytokine release and protein kinase C (PKC) activity of mouse alveolar macrophages. In addition, I examined the relationship between amiodarone and eicosapentaenoic acid (EPA) with respect to the
Azusa Kobayashi et al.
Frontiers in immunology, 12, 650856-650856 (2021-07-03)
Accumulating evidence suggests that cholesterol accumulation in leukocytes is causally associated with the development of autoimmune diseases. However, the mechanism by which fatty acid composition influences autoimmune responses remains unclear. To determine whether the fatty acid composition of diet modulates
Yong-Ping Zhang et al.
Prostaglandins, leukotrienes, and essential fatty acids, 136, 85-94 (2017-08-06)
Omega-3 polyunsaturated fatty acids (n-3 PUFAs), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have been reported to prevent neurodegenerative diseases such as Alzheimer's disease (AD) in both experimental and clinical/epidemiological studies. However, whether DHA and EPA from natural products exert
Takeshi Yamamoto et al.
Autophagy, 17(7), 1700-1713 (2020-06-18)
Recently, we identified a novel mechanism of lipotoxicity in the kidney proximal tubular cells (PTECs); lipid overload stimulates macroautophagy/autophagy for the renovation of plasma and organelle membranes to maintain the integrity of the PTECs. However, this autophagic activation places a

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