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D2773

Sigma-Aldrich

Dithranol

≥90% (HPLC)

Sinônimo(s):

1,8,9-Anthracenetriol, 1,8-Dihydroxy-9(10H)-anthracenone, 1,8-Dihydroxyanthrone, Anthralin

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About This Item

Fórmula empírica (Notação de Hill):
C14H10O3
Número CAS:
1143-38-0
Peso molecular:
226.23
Beilstein:
2054360
Número CE:
214-538-0
Número MDL:
MFCD00053409
Código UNSPSC:
12352201
ID de substância PubChem:
24893712
NACRES:
NA.25
Preço e disponibilidade não estão disponíveis no momento.

Ensaio

≥90% (HPLC)

Formulário

solid

pf

178-181 °C (lit.)

solubilidade

chloroform: 20 mg/mL, clear to very slightly hazy, yellow

cadeia de caracteres SMILES

Oc1cccc2Cc3cccc(O)c3C(=O)c12

InChI

1S/C14H10O3/c15-10-5-1-3-8-7-9-4-2-6-11(16)13(9)14(17)12(8)10/h1-6,15-16H,7H2

chave InChI

NUZWLKWWNNJHPT-UHFFFAOYSA-N

Informações sobre genes

mouse ... Alox12(11684)

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Descrição geral

Dithranol (1, 8 - dihydroxy-9-anthrone) is also called as anthralin. It is a vital topical antipsoriatic drugs.[1] Dithranol, an athracene derivative, is a free radical generating mitochondrial poison that induces apoptosis in keratinocytes.

Aplicação

Dithranol, a potential anti-psoriasis medication, may be used to study its safety, efficacy, metabolism and pharmacological profile. Dithranol may be used to study is physicochemical properties, as a reference compound and to develop effective drug delivery vehicles.[2] Dithranol may be used as a matrix for matrix assisted laser desorption/ionization imaging on a Fourier transform ion cyclotron resonance mass spectrometer.[3]

Outras notas

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
BCBG2227V
BCBG2229V
BCBV0837
BCBN3098V
BCBM5804V

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Os clientes também visualizaram

Slide 1 of 6

1 of 6

2,6,9-ANTHRACENETRIOL AldrichCPR

T303003

2,6,9-ANTHRACENETRIOL

Dithranol British Pharmacopoeia (BP) Reference Standard

BP385

Dithranol

Dithranol European Pharmacopoeia (EP) Reference Standard

D2953000

Dithranol

vibrant-m

D2953025

Dithranol impurity C

vibrant-m

D2953050

Dithranol impurity D

6,8-Dihydroxy-1,3-pyrenedisulfonic acid disodium salt BioReagent, suitable for fluorescence, ≥97.0% (HPCE)

Sigma-Aldrich

37920

6,8-Dihydroxy-1,3-pyrenedisulfonic acid disodium salt

Alison McGill et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 19(8), 1012-1014 (2005-04-02)
Anthralin is a potent topical drug, inducing clearance of psoriatic plaques. Anthralin disrupts mitochondrial function and structure, but its mechanism of action remains undefined. This study aimed to determine whether anthralin induced keratinocyte apoptosis as well as to investigate molecular
Wing Man Lau et al.
Pharmaceutics, 5(2), 232-245 (2013-12-05)
Psoriasis is a common, chronic and relapsing inflammatory skin disease. It affects approximately 2% of the western population and has no cure. Combination therapy for psoriasis often proves more efficacious and better tolerated than monotherapy with a single drug. Combination
Brian L Watson et al.
Physical chemistry chemical physics : PCCP, 17(24), 15788-15796 (2015-05-29)
A new sensitizer motif for dye sensitized solar cells (DSSC) has been developed. A heteroaromatic moiety containing a pyrazine ring links two porphyrin chromophores to the metal oxide surface via two carboxylic acid attachment groups. A test DSSC sensitized with
G C Hsieh et al.
Toxicology and applied pharmacology, 107(1), 16-26 (1991-01-01)
Primary cultured rat epidermal keratinocytes were used as an experimental model to detect oxidant-mediated adverse effects of dithranol (anthralin), a widely used antipsoriasis drug with tumor-promoting and skin-irritating properties. Keratinocytes were isolated and prepared from the skin of neonatal rats
Kaisar Raza et al.
Journal of microencapsulation, 28(3), 190-199 (2011-03-15)
The objective of this study was to develop and characterize a novel dithranol-containing phospholipid microemulsion systems for enhanced skin permeation and retention. Based on the solubility of dithranol, the selected oils were isopropyl myristate (IPM) and tocopherol acetate (TA), and
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