C4780

Coenzima A

BioReagent, suitable for cell culture

• Sinônimo(s): CoA Na₂
• Fórmula empírica (Notação de Hill): C₂₁H₃₆N₇O₁₆P₃S · xNa⁺ · yH₂O
• Número CAS: 55672-92-9
• Peso molecular: 767.53 (anhydrous free acid basis)
• Número CE: 259-747-8
• Número MDL: MFCD00079020
• Código UNSPSC: 12352205
• ID de substância PubChem: 24892723
• NACRES: NA.75

Propriedades

• fonte biológica: yeast
• descrição: cofactor for acyl transfer
• linha de produto: BioReagent
• Ensaio: ≥85% (HPLC)
• Formulário: powder
• técnica(s): cell culture | mammalian: suitable
• solubilidade: water: 50 mg/mL, clear, colorless to faintly yellow
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: [Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
• InChI: 1S/C21H36N7O16P3S.Na/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H
• chave InChI: SYTRWOCXZXQBPW-CLVRNSBASA-M

Descrição

Aplicação

Coenzyme A sodium salt hydrate has been used:

• in the branch chain aminotransferase enzymatic assay and protein determination
• in the assay for halogenation of pyrrolyl-S-Bmp1 (an acyl carrier protein (ACP)-thioesterase (TE) di-domain protein) by Bmp2
• as an extracellular coenzyme A (CoA) in in vitro and in vivo experiments to study alternative routes by which cells and organisms can obtain CoA

Ações bioquímicas/fisiológicas

Coenzyme A (CoA) is a ubiquitous cofactor that plays an important role in many metabolic pathways, mainly as acyl-CoA. It is essential for the tricarboxylic acid cycle, and the synthesis and oxidation of fatty acids. CoA facilitates acyl group transfers, especially in fatty acid and lipid metabolism reactions. It is associated with neurodegeneration, autophagy, protein acetylation, and signal transduction.

Qualidade

Enzymatically assayed using phosphotransacetylase. Approx. 95% CoA-SH

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)