B6938
Bisdemethoxycurcumin
≥98% (HPLC), solid
Sinônimo(s):
(1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
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About This Item
Fórmula empírica (Notação de Hill):
C19H16O4
Número CAS:
Peso molecular:
308.33
Número MDL:
Código UNSPSC:
12352205
ID de substância PubChem:
NACRES:
NA.77
Produtos recomendados
Ensaio
≥98% (HPLC)
forma
solid
solubilidade
DMSO: ≥20 mg/mL
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
Oc1ccc(cc1)\C=C\C(=O)CC(=O)\C=C\c2ccc(O)cc2
InChI
1S/C19H16O4/c20-16-7-1-14(2-8-16)5-11-18(22)13-19(23)12-6-15-3-9-17(21)10-4-15/h1-12,20-21H,13H2/b11-5+,12-6+
chave InChI
PREBVFJICNPEKM-YDWXAUTNSA-N
Aplicação
Bisdemethoxycurcumin has been used:
- to test its inhibitory effect on cell cycle and mitochondrial function in gastric adenocarcinoma cells
- to test it neuroprotective role against lead (Pb) induced toxicity in dopaminergic and noradrenergic systems of Meriones shawi
- as a standard for calibration curve generation to quantify plasma curcuminoids using high-performance liquid chromatography-diode array detection (HPLC-DAD) and ultraviolet (UV)
Ações bioquímicas/fisiológicas
Bisdemethoxycurcumin (BDMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. BDMC shares similar anti-inflammatory properties with demethoxycurcumin. It inhibits LPS-induced nitric oxide (NO) production and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. BDMC also displays unique properties in that it enhances Abeta clearance by upregulating expression MGAT3 and TLR genes. BDMC potently inhibits AKR1B10.
Bisdemethoxycurcumin (BMDC) is a stable dimethoxy derivative of curcumin and is useful as a supplement in cell culture medium. It also possesses antimicrobial, antioxidative and neuroprotective functionality.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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