AV36965
Anti-PTRF antibody produced in rabbit
IgG fraction of antiserum
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100 μL
R$ 2.017,00
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100 μL
R$ 2.017,00
About This Item
R$ 2.017,00
Check Cart for Availability
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
IgG fraction of antiserum
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous solution
peso molecular
43 kDa
reatividade de espécies
mouse, human
concentração
0.5 mg - 1 mg/mL
técnica(s)
immunohistochemistry: suitable
western blot: suitable
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
mouse ... PTRF(19285)
Descrição geral
Polymerase I and transcript release factor (PTRF) contains a leucine zipper motif, a nuclear localization signal, and PEST domains. It is critically involved in termination of transcription by stalling RNA poly I and releasing it from the elongating transcript. PTRF is also found localized to caveolae and regulates formation of the vesicles at the plasma membrane.
Imunogênio
Synthetic peptide directed towards the middle region of mouse PTRF
Ações bioquímicas/fisiológicas
In mouse, pausing of elongation complexes is mediated by the transcription termination factor TTF-I bound to the ′Sal box′ terminator downstream of the rDNA transcription unit. PTRF is a Pol I and transcript release factor for dissociation of paused ternary complexes.
Sequência
Synthetic peptide located within the following region: SEALPEKEGDELGEGERPEDDTAAIELSSDEAVEVEEVIEESRAERIKRS
forma física
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Rahul Chadda et al.
Cell, 132(1), 23-24 (2008-01-15)
Caveolae are small membrane invaginations important for cell signaling that are characterized by the presence of caveolin proteins. Hill et al. (2008) have now identified PTRF as a new constituent of the caveolar coat. In the absence of PTRF, caveolae
Stéphanie Torrino et al.
The Journal of cell biology, 217(12), 4092-4105 (2018-10-24)
Caveolae are small invaginated pits that function as dynamic mechanosensors to buffer tension variations at the plasma membrane. Here we show that under mechanical stress, the EHD2 ATPase is rapidly released from caveolae, SUMOylated, and translocated to the nucleus, where
P Jansa et al.
The EMBO journal, 17(10), 2855-2864 (1998-06-10)
Termination of transcription by RNA polymerase I (Pol I) is a two-step process which involves pausing of elongating transcription complexes and release of both pre-rRNA and Pol I from the template. In mouse, pausing of elongation complexes is mediated by
Vikas A Tillu et al.
Molecular biology of the cell, 26(20), 3561-3569 (2015-08-14)
Caveolae are abundant surface organelles implicated in a range of cellular processes. Two classes of proteins work together to generate caveolae: integral membrane proteins termed caveolins and cytoplasmic coat proteins called cavins. Caveolae respond to membrane stress by releasing cavins
Kerrie-Ann McMahon et al.
eLife, 10 (2021-06-19)
Caveolae-associated protein 3 (cavin3) is inactivated in most cancers. We characterized how cavin3 affects the cellular proteome using genome-edited cells together with label-free quantitative proteomics. These studies revealed a prominent role for cavin3 in DNA repair, with BRCA1 and BRCA1
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