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A8861

Sigma-Aldrich

Aceclofenac

≥98% (HPLC)

Sinônimo(s):

2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester;

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About This Item

Fórmula empírica (Notação de Hill):
C16H13Cl2NO4
Número CAS:
89796-99-6
Peso molecular:
354.18
Número MDL:
MFCD00864296
Código UNSPSC:
12352200
ID de substância PubChem:
329771021
NACRES:
NA.77

R$ 550,00

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Ensaio

≥98% (HPLC)

Formulário

powder

cor

off-white to light tan

solubilidade

DMSO: ≥20 mg/mL

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

OC(=O)COC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl

InChI

1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21)

chave InChI

MNIPYSSQXLZQLJ-UHFFFAOYSA-N

Informações sobre genes

human ... PTGS2(5743)

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Aplicação

Aceclofenac (ACE) has been used as an internal standard in the in vivo blood-brain barrier assay.[1] It has also been used to study the interaction of ACE with bovine serum albumin (BSA) by using spectroscopic techniques in combination with computational methods.[2]

Ações bioquímicas/fisiológicas

Aceclofenac is a phenyl acetic acid derivative used for treating symptoms like swelling, tenderness, and stiffness due to muscle-skeletal and bone-related diseases (rheumatoid arthritis, juvenile arthritis, osteoarthritis, and acute gouty arthritis). This compound shows analgesic and antipyretic properties. Aceclofenac suppresses prostaglandin biosynthesis.[2]
Non-steroidal, anti-inflammatory drug (NSAID), with selectivity for COX-2 over COX-1.

Pictogramas

Skull and crossbonesEnvironment
GHS06,GHS09

Palavra indicadora

Danger

Frases de perigo

H301,H319,H410

Classificações de perigo

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
0000212711
0000212711
0000209085
0000209085
0000189947

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Acetaminofeno BioXtra, ≥99.0%

Sigma-Aldrich

A7085

Acetaminofeno

An insight into the binding of aceclofenac with bovine serum albumin at physiological condition: a spectroscopic and computational approach.
Neeraj Dohare et al.
Journal of biomolecular structure & dynamics, 36(2), 398-406 (2017-01-25)
M Dooley et al.
Drugs, 61(9), 1351-1378 (2001-08-21)
Aceclofenac is an orally administered phenylacetic acid derivative with effects on a variety of inflammatory mediators. Through its analgesic and anti-inflammatory properties, aceclofenac provides symptomatic relief in a variety of painful conditions. In patients with osteoarthritis of the knee, the
Rajesh Katara et al.
Colloids and surfaces. B, Biointerfaces, 103, 455-462 (2012-12-25)
The purpose of this study was to prepare Eudragit RL 100-based nanoparticles of aceclofenac by nanoprecipitation and evaluate the particle size, zeta potential, drug entrapment, particle morphology; in vitro drug release and in vivo efficacy. Change in drug-polymer ratio from
Sanjay Dey et al.
Expert opinion on drug delivery, 9(9), 1041-1050 (2012-07-14)
The objective of the present study was to develop bilayer tablets of aceclofenac that are characterized by initial burst drug release followed by sustained release of drug. The fast-release layer of the bilayer tablet was formulated using microcrystaline cellulose (MCC)
Viney Chawla et al.
Colloids and surfaces. B, Biointerfaces, 92, 293-298 (2012-01-10)
Solid lipid nanoparticles (SLN) of aceclofenac were prepared using Taguchi experimental design by Trotta method. The prepared SLN were formulated into a gel preparation, using carbopol 940. Gels were evaluated for drug content, bioadhesion and their stability against change of
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