A7856
Acipimox
≥99% (TLC)
Sinônimo(s):
2-Carboxy-5-methylpyrazine 4-oxide, 5-Methylpyrazinecarboxylic acid 4-oxide
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About This Item
Fórmula empírica (Notação de Hill):
C6H6N2O3
Número CAS:
Peso molecular:
154.12
Número CE:
Número MDL:
Código UNSPSC:
12352205
NACRES:
NA.79
Preço e disponibilidade não estão disponíveis no momento.
Produtos recomendados
Nível de qualidade
Ensaio
≥99% (TLC)
Formulário
powder
cor
off-white to faint yellow
pf
177-180 °C
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
[n+]1(c(cncc1C(=O)O)C)[O-]
InChI
1S/C6H6N2O3/c1-4-2-7-3-5(6(9)10)8(4)11/h2-3H,1H3,(H,9,10)
chave InChI
DNRXJHATQULEHC-UHFFFAOYSA-N
Categorias relacionadas
Ações bioquímicas/fisiológicas
Acipimox, also known as olbemox,[1] is a nicotinic acid analog.[2] It functions as an anti-lipolytic drug[3] and vasodilator. Acipimox may be used in various metabolic studies involving insulin and ghrelin.[4] It lowers total cholesterol and total triglycerides, which helps in the treatment of hyperlipidemia.[2]
Niacin-derived, vasodilator studied for its lipid-lowering effect.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
dust mask type N95 (US), Eyeshields, Gloves
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Impaired growth hormone secretion in obese subjects is partially reversed by acipimox-mediated plasma free fatty acid depression
Cordido F, et al.
The Journal of clinical endocrinology and metabolism, 81(3), 914-918 (1996)
Fabrizio Montecucco et al.
American journal of physiology. Endocrinology and metabolism, 300(4), E681-E690 (2011-01-27)
Metabolic syndrome is a proatherosclerotic condition clustering cardiovascular risk factors, including glucose and lipid profile alterations. The pathophysiological mechanisms favoring atherosclerotic inflammation in the metabolic syndrome remain elusive. Here, we investigated the potential role of the antilipolytic drug acipimox on
Mads Halbirk et al.
American journal of physiology. Heart and circulatory physiology, 299(4), H1220-H1225 (2010-08-17)
Circulating free fatty acids (FFAs) may worsen heart failure (HF) due to myocardial lipotoxicity and impaired energy generation. We studied cardiac and whole body effects of 28 days of suppression of circulating FFAs with acipimox in patients with chronic HF.
Lars C Gormsen et al.
European journal of endocrinology, 154(5), 667-673 (2006-04-29)
Concentrations of the orexigenic peptide ghrelin is affected by a number of hormones, which also affect circulating levels of free fatty acids (FFAs). The present study was therefore designed to determine the direct effect of FFAs on circulating ghrelin. Eight
Jara Nedvidkova et al.
Regulatory peptides, 167(1), 134-139 (2011-01-18)
Ghrelin is predominantly produced by the stomach and the growth hormone (GH)-ghrelin feedback loop between the stomach and the pituitary gland has recently been suggested. The disruption of the gut-brain axis might be involved in bulimia nervosa (BN). We investigated
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