A7275

L-2-Aminoadipic acid

≥98% (TLC), powder, glutamine synthetase inhibitor

• Sinônimo(s): (S)-2-Aminohexanedioic acid, L-Homoglutamic acid, Aad
• Fórmula linear: HO₂C(CH₂)₃CH(NH₂)CO₂H
• Número CAS: 1118-90-7
• Peso molecular: 161.16
• Beilstein: 1724348
• Número MDL: MFCD00002636
• Código UNSPSC: 12352209
• ID de substância PubChem: 24278234
• NACRES: NA.32

Propriedades

• product name: L-2-Aminoadipic acid, ≥98% (TLC)
• Ensaio: ≥98% (TLC)
• forma: powder
• pf: 203-205 °C (dec.) (lit.)
• cadeia de caracteres SMILES: N[C@@H](CCCC(O)=O)C(O)=O
• InChI: 1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
• chave InChI: OYIFNHCXNCRBQI-BYPYZUCNSA-N
• Informações sobre genes: human ... GLUL(2752) , LGSN(51557) ; rat ... Grm1(24414) , Grm2(24415) , Grm4(24417) , Grm5(24418) , Grm6(24419)

Descrição

Descrição geral

L-2-Aminoadipic acid/α-aminoadipate is a gliotoxin and is a structural analog of glutamine. It is generated by the catabolism of lysine saccharopine (SAC)/pipecolic acid (PIP) pathways.

Aplicação

L-2-Aminoadipic acid has been used as a gliotoxin specific for astrocytes in rat. It has also been as an internal standard in the amino acid analysis from fermented food sample.

Ações bioquímicas/fisiológicas

L-2-Aminoadipic acid inhibits glutamine synthetase and γ-glutamylcysteine synthetase. It modulates glucose metabolism and is present in higher levels in diabetic patients. L-2-Aminoadipic acid plays a key role in suppressing autophagy in C2C12 myotubes.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)