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A6339

Sigma-Aldrich

N-Acetyl-Val-Glu-Ile-Asp-al

~99% (HPLC), powder

Sinônimo(s):

Ac-VEID-CHO

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About This Item

Fórmula empírica (Notação de Hill):
C22H36N4O9
Número CAS:
319494-39-8
Peso molecular:
500.54
Número MDL:
MFCD01318861
Código UNSPSC:
12352209
ID de substância PubChem:
329770890
NACRES:
NA.32

Ensaio

~99% (HPLC)

Nível de qualidade

200

forma

powder

cor

white

solubilidade

H2O: 1 mg/mL

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N[C@@H](CC(O)=O)C=O

InChI

1S/C22H36N4O9/c1-6-12(4)19(22(35)24-14(10-27)9-17(31)32)26-20(33)15(7-8-16(29)30)25-21(34)18(11(2)3)23-13(5)28/h10-12,14-15,18-19H,6-9H2,1-5H3,(H,23,28)(H,24,35)(H,25,34)(H,26,33)(H,29,30)(H,31,32)/t12-,14-,15-,18-,19-/m0/s1

chave InChI

KYUFGGNCJRWMDN-GOYXDOSHSA-N

Informações sobre genes

human ... CASP6(839)

Amino Acid Sequence

NAc-Val-Glu-Ile-Asp-al

Ações bioquímicas/fisiológicas

Caspase 6 inhibitor.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Callinice D Capo-chichi et al.
Molecular and cellular biology, 29(17), 4766-4777 (2009-07-08)
A prominent hallmark of most human cancer is aneuploidy, which is a result of the chromosomal instability of cancer cells and is thought to contribute to the initiation and progression of most carcinomas. The developmentally regulated GATA6 transcription factor is
Ali Khoshnan et al.
PloS one, 4(6), e5768-e5768 (2009-06-03)
Proteolysis of huntingtin (Htt) plays a key role in the pathogenesis of Huntington's disease (HD). However, the environmental cues and signaling pathways that regulate Htt proteolysis are poorly understood. One stimulus may be the DNA damage that accumulates in neurons
Roman E Beloshistov et al.
The New phytologist, 218(3), 1167-1178 (2017-04-14)
Peptide hormones are implicated in many important aspects of plant life and are usually synthesized as precursor proteins. In contrast to animals, data for plant peptide hormone maturation are scarce and the specificity of processing enzyme(s) is largely unknown. Here
Dagmar E Ehrnhoefer et al.
PloS one, 6(11), e27680-e27680 (2011-12-06)
Aberrant activation of caspase-6 has recently emerged as a major contributor to the pathogeneses of neurodegenerative disorders such as Alzheimer's and Huntington disease. Commercially available assays to measure caspase-6 activity commonly use the VEID peptide as a substrate. However these
Gustavo Lemos Rocha et al.
Plant science : an international journal of experimental plant biology, 288, 110232-110232 (2019-09-16)
Seed coat is the tissue which establishes an interface between the seed inner tissues and external environment. Our group has shown that cowpea seed coat undergoes coordinated events of programmed cell death (PCD) during development. In relation to germinating seed
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