A3145

Apigenin

≥97% (TLC), from parsley, powder

• Sinônimo(s): 4′,5,7-Trihydroxyflavone, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
• Fórmula empírica (Notação de Hill): C₁₅H₁₀O₅
• Número CAS: 520-36-5
• Peso molecular: 270.24
• Beilstein: 262620
• Número CE: 208-292-3
• Número MDL: MFCD00006831
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278212

Propriedades

• fonte biológica: parsley
• Ensaio: ≥97% (TLC)
• Formulário: powder
• cor: yellow
• pf: >300 °C (lit.)
• solubilidade: DMSO: 27 mg/mL; 1 M KOH: 50 mg/mL
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
• InChI: 1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
• chave InChI: KZNIFHPLKGYRTM-UHFFFAOYSA-N
• Informações sobre genes: human ... ADORA3(140) , CDC2(983) , CDK5(1020) , CDK6(1021) , CYP1A2(1544) , ESR1(2099) , ESR2(2100) , GSK3A(2931) ; mouse ... Hexa(15211) ; rat ... Adora1(29290) , Adora2a(25369) , Il4(287287) , Tnf(24835)

Descrição

Ações bioquímicas/fisiológicas

A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G₂/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.

A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G₂/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibitory effects on tumor promotion may also be due to inhibition of kinase activity and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I catalyzed DNA religation and enhance gap junctional intercellular communication.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves