A0487

Argatroban monohydrate

≥98% (HPLC)

• Sinônimo(s): (2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic Acid, Argipidine, MQPA
• Fórmula empírica (Notação de Hill): C₂₃H₃₆N₆O₅S · H₂O
• Número CAS: 141396-28-3
• Peso molecular: 526.65
• Número MDL: MFCD23105684
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• condição de armazenamento: desiccated
• cor: white to off-white
• solubilidade: DMSO: ≥20 mg/mL
• originador: Baxter
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: [S](=O)(=O)(NC(CCCNC(=N)N)C(=O)N3[C@H](C[C@@H](CC3)C)C(=O)O)c1c2c(ccc1)CC(CN2)C.O
• InChI: 1S/C23H36N6O5S.H2O/c1-14-8-10-29(18(12-14)22(31)32)21(30)17(6-4-9-26-23(24)25)28-35(33,34)19-7-3-5-16-11-15(2)13-27-20(16)19;/h3,5,7,14-15,17-18,27-28H,4,6,8-13H2,1-2H3,(H,31,32)(H4,24,25,26);1H2/t14-,15?,17?,18-;/m1./s1
• chave InChI: AIEZTKLTLCMZIA-LINCPPCXSA-N

Descrição

Descrição geral

Argatroban anticoagulant is synthesized from L-arginine [1] and photodegrades under light exposure.[2]

Aplicação

Argatroban monohydrate has been used as a thrombin-selective inhibitor in the thrombin assay of platelet poor plasma samples[3]. It may be used as a standard in gradient reversed-phase liquid chromatography coupled with high-resolution multistage mass spectrometry (LC/HR-MSⁿ) for photoproducts fragmentation analysis[2] and as a thrombin inhibitor competitive assay with fullerene-based C60 nanoparticle (NPs).[4]

Ações bioquímicas/fisiológicas

Argatroban has a high affinity[5] and binds to arginine in thrombin active site resulting in steric hindrance for substrate binding.[1] Argatroban is effective in preventing thrombus formation and favors thrombolysis than unfractionated heparin.[1] It is recommended for acute ischemic stroke treatment.[5]

Argatroban is a potent, selective, direct inhibitor of thrombin and a clinical anticoagulant.

Argatroban is a potent, seletive, univalent direct inhibitor of thrombin. It directly inhibits thrombin by binding only to its active site (thus univalent) as compared to Bivalent DTIs (hirudin and analogs) which bind both to the active site and exosite 1.

Características e benefícios

This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable