Synthetic oligonucleotides are increasingly used because of their potential activity as regulators of gene expression. One of their major drawbacks is instability toward nucleases, in particular exonucleases. In this article, we studied some terminal modifications that can enhance exonuclease resistance
Molecular and cellular biology, 23(2), 534-542 (2003-01-02)
The nuclear pore complex (NPC) is a permeable sieve that can dilate to facilitate the bidirectional translocation of a wide size range of receptor-cargo complexes. The binding of receptors to FG nucleoporin docking sites triggers channel gating by an unknown
The optimum concentration and application time for an experimental dentin primer composed of an aqueous solution of 1,6-hexanediol were determined by measuring the wall-to-wall polymerization contraction gap width of a commercial light-activated resin composite in a cylindrical dentin cavity prepared
Journal of neurocytology, 9(4), 505-516 (1980-08-01)
This study examined the thesis that 2,5-dexanedione (2,5-HD) produces distal (dying-back) axonopathy by direct toxic action on nerve fibers. Single or repeated application of undiluted or 10% 2,5-HD to exposed rat sciatic nerves caused some fibres to develop focal axonal
The journal of physical chemistry. B, 111(45), 13101-13106 (2007-10-26)
The solution structure of a synthetic DNA mini-hairpin possessing a stilbenediether linker and three G:C base pairs has been obtained using (1)H NMR spectral data and constrained torsion angle molecular dynamics. Notable features of this structure include a compact hairpin
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