78825
Liquiritigenin
≥97.0% (HPLC)
Sinônimo(s):
7,4′-Dihydroxyflavanone, 7-Hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one
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10 MG
R$ 905,00
50 MG
R$ 3.571,00
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10 MG
R$ 905,00
50 MG
R$ 3.571,00
About This Item
Fórmula empírica (Notação de Hill):
C15H12O4
Número CAS:
Peso molecular:
256.25
Beilstein:
359378
Número MDL:
Código UNSPSC:
12352202
ID de substância PubChem:
NACRES:
NA.28
Produtos recomendados
Ensaio
≥97.0% (HPLC)
Formulário
powder or crystals
Impurezas
≤7% water
aplicação(ões)
metabolomics
vitamins, nutraceuticals, and natural products
cadeia de caracteres SMILES
Oc1ccc(cc1)[C@@H]2CC(=O)c3ccc(O)cc3O2
InChI
1S/C15H12O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-7,14,16-17H,8H2/t14-/m0/s1
chave InChI
FURUXTVZLHCCNA-AWEZNQCLSA-N
Categorias relacionadas
Descrição geral
Liquiritigenin is a flavonoid and an estrogenic compound found in licorice (Glycyrrhizae radix) root extract and several other plants.[1]
Aplicação
Liquiritigenin has been used:
- to study its inhibitory effect on tumor metastasis in the treatment of colorectal cancer[2]
- as a reference standard for ultra-performance liquid chromatography (UPLC) of Chaihu-Shugan-San (CSS) extract[3]
- as a potential antiviral drug against hepatitis C virus (HCV) infection[4]
Ações bioquímicas/fisiológicas
Liquiritigenin displays anti-diabetic[1] and choleretic[5] properties. It exerts anti-inflammatory activity on Raw246.7 cells by inhibiting nuclear factor kappa light chain enhancer of activated B cells (NF-κB)-dependent-induction of inducible NOS (iNOS).[6] Liquiritigenin inhibits liver fibrogenesis by blocking Hippo/Yes-associated protein (YAP) and transforming growth factor-β1 (TGF-β1)/small mothers against decapentaplegic (Smad) components.[7] It is a selective estrogen receptor β agonist[8] cells.[9] Liquiritigenin induces apoptosis in SMM-721 cells by disruption of the mitochondrial membrane potential and increased production of reactive oxygen species.[10]
Embalagem
Bottomless glass bottle. Contents are inside inserted fused cone.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Rui Ting Liu et al.
European journal of pharmacology, 669(1-3), 76-83 (2011-08-30)
The present paper is to examine whether liquiritigenin is able to attenuate the Alzheimer's-like learning and memory deficits in a transgenic (Tg) mouse model that over-expresses amyloid protein precursor (APP), and explores the underlying mechanisms. Consistent with our previous observations
Suengmok Cho et al.
Bioorganic & medicinal chemistry, 20(11), 3493-3501 (2012-05-01)
Licorice (Glycyrrhiza glabra, GG) is one of the most frequently used herbal medicines worldwide, and its various biological activities have been widely studied. GG is reported to have neurological properties such as antidepressant, anxiolytic, and anticonvulsant effects. However, its hypnotic
Eun Mi Choi
International immunopharmacology, 12(1), 139-143 (2011-11-26)
Liquiritigenin is one of the flavonoids present in Glycyrrhizae radix. In the present study, the effects of liquiritigenin on the function of osteoblastic MC3T3-E1 cells were studied. Liquiritigenin caused a significant elevation of cell growth, alkaline phosphatase activity, collagen synthesis
Young Woo Kim et al.
American journal of physiology. Gastrointestinal and liver physiology, 296(2), G372-G381 (2008-12-17)
Liquiritigenin (LQ), an active component of licorice, has an inhibitory effect on LPS-induced inhibitory nitric oxide synthase expression. This study investigated the effects of LQ on choleresis, the expression of hepatic transporters and phase-II enzymes, and fulminant hepatitis. The choleretic
Jennifer E Mersereau et al.
Molecular and cellular endocrinology, 283(1-2), 49-57 (2008-01-08)
After the Women's Health Initiative found that the risks of hormone therapy outweighed the benefits, a need for alternative drugs to treat menopausal symptoms has emerged. We explored the possibility that botanical agents used in Traditional Chinese Medicine for menopausal
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