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49549

Sigma-Aldrich

4-Hydroxy-L-isoleucine

≥98.0% (TLC)

Sinônimo(s):

(2S,3R)-2-Amino-4-hydroxy-3-methylpentanoic acid

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About This Item

Fórmula empírica (Notação de Hill):
C6H13NO3
Número CAS:
781658-23-9
Peso molecular:
147.17
Número MDL:
MFCD06799350
Código UNSPSC:
12352204
eCl@ss:
32160406
ID de substância PubChem:
329757475
NACRES:
NA.32

product name

4-Hydroxy-L-isoleucine, ≥98.0% (TLC)

Ensaio

≥98.0% (TLC)

atividade óptica

[α]/D +34.0±2.0°, c = 1 in H2O

cor

white to off-white

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CC(O)[C@H](C)[C@H](N)C(O)=O

InChI

1S/C6H13NO3/c1-3(4(2)8)5(7)6(9)10/h3-5,8H,7H2,1-2H3,(H,9,10)/t3-,4?,5-/m0/s1

chave InChI

OSCCDBFHNMXNME-DSDZBIDZSA-N

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Ações bioquímicas/fisiológicas

A peculiar amino acid extracted from fenugreek seeds and never found in mammalian tissues, exhibits interesting insulinotropic activity; effects on insulin secretion, plant-derived treatment for metabolic syndrome.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Declarações de precaução

P261 - P305 + P351 + P338

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

296.6 °F

Ponto de fulgor (°C)

147 °C

Certificados de análise (COA)

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C Broca et al.
European journal of pharmacology, 390(3), 339-345 (2000-03-10)
4-Hydroxyisoleucine, a peculiar amino acid extracted from fenugreek seeds and never found in mammalian tissues, exhibits interesting insulinotropic activity. To investigate the structural requirements for this stimulating effect, the insulinotropic activity of the major isomer (2S,3R,4S) of 4-hydroxyisoleucine, in the
Choong Tat Keng et al.
Gut, 65(10), 1744-1753 (2015-07-08)
HCV infection affects millions of people worldwide, and many patients develop chronic infection leading to liver cancers. For decades, the lack of a small animal model that can recapitulate HCV infection, its immunopathogenesis and disease progression has impeded the development
Anna Maria Herzner et al.
PloS one, 6(7), e22389-e22389 (2011-08-04)
Lantibiotics are small peptide antibiotics that contain the characteristic thioether amino acids lanthionine and methyllanthionine. As ribosomally synthesized peptides, lantibiotics possess biosynthetic gene clusters which contain the structural gene (lanA) as well as the other genes which are involved in
Jasmin Dischinger et al.
PloS one, 4(8), e6788-e6788 (2009-08-27)
Lantibiotics are small microbial peptide antibiotics that are characterized by the presence of the thioether amino acids lanthionine and methyllanthionine. Lantibiotics possess structural genes which encode inactive prepeptides. During maturation, the prepeptide undergoes posttranslational modifications including the introduction of rare
Dong Hoon Shin et al.
Annals of laboratory medicine, 34(4), 307-312 (2014-07-02)
Hemolysis, icterus, and lipemia (HIL) cause preanalytical interference and vary unpredictably with different analytical equipments and measurement methods. We developed an integrated reporting system for verifying HIL status in order to identify the extent of interference by HIL on clinical
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