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453R-1

Sigma-Aldrich

p53 (SP5) Rabbit Monoclonal Antibody

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100
500

conjugado

unconjugated

forma do anticorpo

culture supernatant

tipo de produto de anticorpo

primary antibodies

clone

SP5, monoclonal

descrição

For In Vitro Diagnostic Use in Select Regions (See Chart)

forma

buffered aqueous solution

reatividade de espécies

human

embalagem

vial of 0.1 mL concentrate (453R-14)
vial of 0.5 mL concentrate (453R-15)
bottle of 1.0 mL predilute (453R-17)
vial of 1.0 mL concentrate (453R-16)
bottle of 7.0 mL predilute (453R-18)

fabricante/nome comercial

Cell Marque™

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

Isotipo

IgG1

controle

colon carcinoma

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

visualização

nuclear

Informações sobre genes

human ... TP53(7157)

Descrição geral

Anti-p53 tumor suppressor protein antibody recognizes a 53 kDa phosphoprotein, identified as p53 suppressor gene product. It reacts with the mutant as well as wild type p53, although significant accumulation of the mutant form of p53 protein due to longer half-life half-life is the basis for the test using the IHC technique. Quantitation of nuclear staining with this antibody has been shown to be a factor in breast carcinoma, lung carcinoma, colorectalcarcinoma, urothelial carcinoma, and ependymoma. p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia.

Ligação

p53 Positive Control Slides, Product No. 453S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparo

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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A Korshunov et al.
Journal of the neurological sciences, 177(1), 72-82 (2000-09-01)
Intracranial ependymomas are the third most common primary brain tumor in children. Although clinical and histological criteria for ependymoma prognosis are recognized, studies have reported contradictory results. Prognostic significance based on immunohistochemistry of ependymomas has been reported in a few
Diagnostic Immunohistochemistry: Theranostic and Genomic Applications (2006)
B E Moore et al.
Applied immunohistochemistry & molecular morphology : AIMM, 9(3), 203-206 (2001-09-15)
Intratubular germ cell neoplasia, unclassified (IGCNU) is a precursor of germ cell tumors (GCT) of the testis. In routine histologic sections, neoplastic intratubular germ cells may be very few and easily overlooked. The aim of this study is two-fold: to
D C Quinlan et al.
Cancer research, 52(17), 4828-4831 (1992-09-01)
Mutations in the gene coding for the p53 tumor suppressor protein are common in a variety of human cancers. To assess the role of a putative mutated p53 protein in human lung cancer, a monoclonal antibody recognizing it was used
C Midulla et al.
Anticancer research, 19(5B), 4033-4037 (2000-01-11)
The different clinical evolution of breast cancer with similar pathological characteristics prompted the authors to investigate the prognostic significance of different biological markers. Seventy-one primary breast carcinoma specimens obtained by mastectomy or quadrantectomy were examined for the determination of the
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