SAB4500003

Anti-BCL-2 antibody produced in rabbit

affinity isolated antibody

• Sinônimo(s): Apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, BCL2
• Número MDL: MFCD00239644
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• forma: buffered aqueous solution
• peso molecular: antigen 26 kDa
• reatividade de espécies: rat, mouse, human
• concentração: ~1 mg/mL
• técnica(s): ELISA: 1:10000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• nº de adesão NCBI: P10415
• nº de adesão UniProt: P10415
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... BCL2(596)

Descrição

Descrição geral

B-cell lymphoma 2 (BCL-2) is an integral inner mitochondrial membrane protein that acts as an antiapoptotic protein. It is a target gene of nuclear factor kappa B (NF-kB). The gene encoding BCL-2 is localized on human chromosome 18q21.

Imunogênio

The antiserum was produced against synthesized peptide derived from human BCL-2.

Immunogen Range: 46-95

Aplicação

Anti-BCL-2 antibody produced in rabbit has been used in western blotting.

Ações bioquímicas/fisiológicas

BCL2 is an apoptosis regulator that is expressed in sub-cellular components such as the mitochondria and nucleus. While mitochondrial BCL2 inhibits apoptosis, BCL2 present in the nucleus may activate cell death. BCL2 may also regulate autophagy during starvation . Anti-BCL-2 antibodies are specific for endogenous levels of total BCL-2 protein in rats, humans and mice.

Características e benefícios

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forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): nwg
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable