Pular para o conteúdo
Merck
Todas as fotos(1)

Key Documents

443R-1

Sigma-Aldrich

Nanog (EP225) Rabbit Monoclonal Primary Antibody

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Código UNSPSC:
12352203

fonte biológica

rabbit

conjugado

unconjugated

forma do anticorpo

culture supernatant

tipo de produto de anticorpo

primary antibodies

clone

EP225, monoclonal

descrição

For In Vitro Diagnostic Use in Select Regions

forma

buffered aqueous solution

reatividade de espécies

human

embalagem

vial of 0.1 mL concentrate (443R-14)
vial of 0.1 mL concentrate Research Use Only (443R-14-RUO)
vial of 0.5 mL concentrate (443R-15)
vial of 1.0 mL concentrate (443R-16)
vial of 1.0 mL concentrate Research Use Only (443R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (443R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (443R-17)
vial of 7.0 mL pre-dilute ready-to-use (443R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (443R-18-RUO)

fabricante/nome comercial

Cell Marque™

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200 (concentrated)

Isotipo

IgG

controle

seminoma

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

visualização

nuclear

Informações sobre genes

human ... NANOG(79923)

Categorias relacionadas

Descrição geral

Nanog is a transcription factor homeoprotein that is involved in maintaining embryonic stem cell pluripotency and self-renewal. Embryonic stem cells with a deleted Nanog gene lose pluripotency. Conversely, embryonic stem cells that are forced to differentiate will downregulate Nanog expression. Nanog expression has been shown to be absent in normal adult organ tissues, but positive expression in undifferentiated germ cell tumors such as seminoma, dysgerminoma and embryonal carcinoma has been noted. Therefore, Nanog may be used as an aid in the determination of undifferentiated tumors of germ cell origin from non-germ cell tumors.

Qualidade


IVD
IVD
IVD
RUO

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparo

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Download the latest released IFU
Note: This IFU may not apply to your specific product lot.

Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Não está encontrando o produto certo?  

Experimente o nosso Ferramenta de seleção de produtos.

Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Ian Chambers et al.
Cell, 113(5), 643-655 (2003-06-06)
Embryonic stem (ES) cells undergo extended proliferation while remaining poised for multilineage differentiation. A unique network of transcription factors may characterize self-renewal and simultaneously suppress differentiation. We applied expression cloning in mouse ES cells to isolate a self-renewal determinant. Nanog
Martin C Chang et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 28(4), 347-355 (2009-06-02)
The embryonic stem cell transcription factors SOX2, NANOG, and OCT3/4 are involved in the regulation of germ cell tumor growth and differentiation. They, and D2-40 (podoplanin), an antigen expressed in seminomas, are emerging as useful diagnostic markers in testicular germ
Adam H Hart et al.
Cancer, 104(10), 2092-2098 (2005-10-06)
The NANOG gene, a member of the homeobox family of DNA binding transcription factors, was recently identified in a screen for pluripotency-promoting genes. NANOG overexpression in murine embryonic stem cells is sufficient to maintain self-renewal and to block differentiation. The
Guangjin Pan et al.
Cell research, 17(1), 42-49 (2007-01-11)
Several extrinsic signals such as LIF, BMP and Wnt can support the self-renewal and pluripotency of embryonic stem (ES) cells through regulating the "pluripotent genes." A unique homeobox transcription factor, Nanog, is one of the key downstream effectors of these
Kaoru Mitsui et al.
Cell, 113(5), 631-642 (2003-06-06)
Embryonic stem (ES) cells derived from the inner cell mass (ICM) of blastocysts grow infinitely while maintaining pluripotency. Leukemia inhibitory factor (LIF) can maintain self-renewal of mouse ES cells through activation of Stat3. However, LIF/Stat3 is dispensable for maintenance of

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica