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Documentos

327R-1

Sigma-Aldrich

PSMA (EP192) Rabbit Monoclonal Primary Antibody

Sinônimo(s):

Prostate-specific membrane antigen

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About This Item

Código UNSPSC:
12352203

fonte biológica

rabbit

Nível de qualidade

100
500

conjugado

unconjugated

forma do anticorpo

culture supernatant

tipo de produto de anticorpo

primary antibodies

clone

EP192, monoclonal

descrição

For In Vitro Diagnostic Use in Select Regions

forma

buffered aqueous solution

reatividade de espécies

human

embalagem

vial of 0.1 mL concentrate (327R-14)
vial of 0.1 mL concentrate Research Use Only (327R-14-RUO)
vial of 0.5 mL concentrate (327R-15)
vial of 1.0 mL concentrate (327R-16)
vial of 1.0 mL concentrate Research Use Only (327R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (327R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (327R-17)
vial of 7.0 mL pre-dilute ready-to-use (327R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (327R-18-RUO)

fabricante/nome comercial

Cell Marque™

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:40 (concentrated)

Isotipo

IgG

controle

prostate

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

visualização

cytoplasmic, membranous

Informações sobre genes

human ... FOLH1(2346)

Categorias relacionadas

Descrição geral

Prostate-specific membrane antigen (PSMA) is a type II transmembrane glycoprotein with enzymatic activity. PSMA is expressed in normal prostate epithelial cells as well as prostate neoplastic cells. It has been demonstrated that PSMA expression is increased in prostate cancer and is correlated with disease progression. Although highly sensitive and specific for prostate, PSMA also labels a subset of non-prostate tissues, including the small intestine and kidney. PSMA is useful for identifying metastatic prostate carcinoma and distinguishing prostate carcinoma from urothelial carcinoma.

Qualidade


IVD
IVD
IVD
RUO

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparo

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Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 2

Certificados de análise (COA)

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Arundhati Ghosh et al.
Journal of cellular biochemistry, 91(3), 528-539 (2004-02-03)
Prostate specific membrane antigen (PSMA), is a unique membrane bound glycoprotein, which is overexpressed manifold on prostate cancer as well as neovasculature of most of the solid tumors, but not in the vasculature of the normal tissues. This unique expression
Woo Jin Oh et al.
Journal of pathology and translational medicine, 50(5), 345-354 (2016-08-09)
The pathologic distinction between high-grade prostate adenocarcinoma (PAC) involving the urinary bladder and high-grade urothelial carcinoma (UC) infiltrating the prostate can be difficult. However, making this distinction is clinically important because of the different treatment modalities for these two entities.
Sam S Chang
Reviews in urology, 6 Suppl 10, S13-S18 (2006-09-21)
Efforts to evaluate and discover diagnostic and therapeutic markers for prostate cancer continue. One of these, prostate-specific membrane antigen (PSMA), a transmembrane protein expressed in all types of prostatic tissue, remains a useful diagnostic and possibly therapeutic target. The radio-immunoconjugate
Kurt D Bernacki et al.
Diagnostic cytopathology, 42(7), 570-575 (2013-11-26)
The diagnosis of metastatic prostate carcinoma frequently requires the use of immunohistochemical adjuncts. Immunohistochemistry for prostate-specific antigen (PSA) is commonly used for this purpose but can be of limited utility. Recently, prostate-specific membrane antigen (PSMA) has been shown to be
D A Silver et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 3(1), 81-85 (1997-01-01)
Prostate-specific membrane antigen is a type II membrane protein with folate hydrolase activity produced by prostatic epithelium. The expression of this molecule has also been documented in extraprostatic tissues, including small bowel and brain. In the present study, an extensive

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